Nucleating actin for invasion

被引：214

作者：

Nurnberg, Alexander ^{[1
]}

Kitzing, Thomas ^{[2
]}

Grosse, Robert ^{[1
]}

机构：

[1] Univ Marburg, Inst Pharmacol, D-35032 Marburg, Germany

[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 03期

关键词：

SQUAMOUS-CELL CARCINOMA; ALDRICH-SYNDROME PROTEIN; GROWTH-FACTOR RECEPTOR; EXTRACELLULAR-MATRIX DEGRADATION; CHROMOSOME; 11Q13; AMPLIFICATION; PRIMARY MAMMARY-TUMORS; PROSTATE-CANCER CELLS; PRIMARY BREAST-CANCER; N-WASP; ARP2/3; COMPLEX;

D O I：

10.1038/nrc3003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in metastasis, which is the leading cause of death from cancer. Invasive cell migration requires the formation of various structures, such as invadopodia and pseudopodia, which require actin assembly that is regulated by specialized actin nucleation factors. There is a large variety of different actin nucleators in human cells, such as formins, spire and Arp2/3-regulating proteins, and the list is likely to grow. Studies of the mechanisms of various actin nucleation factors that are involved in cancer cell function may ultimately provide new treatments for invasive and metastatic disease.

引用

页码：177 / 187

页数：11

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