Development of novel techniques to extract phenolic compounds from Romanian cultivars of Prunus domestica L. and their biological properties

被引:38
作者
Mocan, Andrei [1 ]
Diuzheva, Mina [2 ]
Carradori, Simone [3 ]
Andruch, Vasil [2 ]
Massafra, Chiara [3 ]
Moldovan, Cadmiel [1 ]
Sisea, Cristian [4 ]
Petzer, Jacobus P. [5 ,6 ]
Petzer, Anel [5 ,6 ]
Zara, Susi [3 ]
Marconi, Guya Diletta [3 ]
Zengin, Gokhan [7 ]
Crisan, Gianina [1 ]
Locatelli, Marcello [3 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmaceut Bot, Cluj Napoca 400337, Romania
[2] Pavol Jozef Safarik Univ, Dept Analyt Chem, Kosice, Slovakia
[3] Univ G dAnnunzio, Dept Pharm, I-66100 Chieti, Italy
[4] Univ Agr Sci & Vet Med, Dept Hort, Manastur 3-5, Cluj Napoca 400372, Romania
[5] North West Univ, Pharmaceut Chem, ZA-2520 Potchefstroom, South Africa
[6] North West Univ, Ctr Excellence Pharmaceut Sci, ZA-2520 Potchefstroom, South Africa
[7] Selcuk Univ, Fac Sci, Dept Biol, Konya, Turkey
关键词
DLLME; SULLE; MAE; HPLC-PDA; Prunus domestica L; Biological activities; MICROWAVE-ASSISTED EXTRACTION; LIQUID-LIQUID-EXTRACTION; ANTIOXIDANT ACTIVITY; ALPHA-GLUCOSIDASE; IN-VITRO; PLUM CULTIVARS; FRUIT; INHIBITORS; FLAVONOIDS; LEAVES;
D O I
10.1016/j.fct.2018.04.045
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
In the present work, fourteen cultivars of Prunus domestica were analyzed to investigate their phenolic pattern with the purpose of using the leaves as potential resources of bioactive compounds in the pharmaceutical and food industry. Microwave-assisted extraction (MAE), dispersive liquid liquid microextraction and sugaring-out liquid liquid extraction techniques were optimized in order to obtain an exhaustive multi-component panel of phenolic compounds. The best phenolic-enriched recovery was achieved using MAE in water:methanol (30:70), and this procedure was further applied for quantitative analysis of phenolic compounds in real samples. In order to prove the safeness of these extracts, the biological potential of the Prunus cultivars was tested by several in vitro antioxidant and enzyme inhibitory assays. Moreover, their cytotoxicity was evaluated on human gingival fibroblasts (HGFs), and in most of the cases the treatment with different concentrations of extracts didn't show cytotoxicity up to 500 mu g/mL. Only 'Carpatin' and 'Minerva' cultivars, at 250 and 500 mu g/mL, reduced partially cell viability of HGFs population. Noteworthy, Centenar cultivar was the most active for the alpha-glucosidase inhibition (6.77 mmolACAE/g extract), whereas Ialomita cultivar showed the best antityrosinase activity (23.07 mgKAE/g extract). Overall, leaves of P. domestica represent a rich alternative source of bioactive compounds.
引用
收藏
页码:189 / 198
页数:10
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