Hepatic Angiosarcoma Post-Renal Transplantation: A Case Report

被引:0
作者
Tong, Show-Hwa [1 ]
Huang, Yen-Ju [2 ]
Yang, Yung-Cheng [3 ]
Lin, Hui-Chuan [1 ]
Jou, Yeong-Chin [3 ,4 ,5 ,6 ]
机构
[1] Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Pharm, Chiayi, Taiwan
[2] Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Pathol, Chiayi, Taiwan
[3] Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Surg, Chiayi, Taiwan
[4] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan
[5] St Martin Porres Hosp, Div Urol, Dept Surg, Chia Yi City, Taiwan
[6] St Martin De Porres Hosp, Div Urol, Dept Surg, 565 Sec 2 Ta-Ya Rd, Chiayi, Taiwan
关键词
NONFUNCTIONING ARTERIOVENOUS-FISTULA; HEPATOCELLULAR-CARCINOMA; KIDNEY-TRANSPLANTATION; RENAL-TRANSPLANTATION; CALCINEURIN INHIBITOR; CANCER INCIDENCE; SIROLIMUS; RISK; IMMUNOSUPPRESSION; MALIGNANCY;
D O I
10.1016/j.transproceed.2022.05.015
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. DNA damage and oncogenic viruses increase the risk of cancer post-kidney transplantation, including skin cancer, Kaposi's sarcoma, oral cancer, and non-Hodgkin lym- phoma. Here we report an uncommon case of liver angiosarcoma that occurred 8 years after kid- ney transplantation. This study strictly complied with the Helsinki Congress and the Istanbul Declaration regarding donor source.Case report. A 57-year-old female patient received a cadaver kidney transplantation 8 years ago. She followed a long-term regimen of tacrolimus, mycophenolate sodium, and everolimus, with good renal function. She received annual regular abdominal ultrasound examinations after kidney transplantation, which showed no findings. The patient suffered from several symptoms for approximately 2 weeks before a scheduled abdominal ultrasound: diarrhea, epigastric pain, abdominal fullness, tea-colored urine, and little stool passage. The abdominal computerized tomography showed multiple hepatic tumors in both the hepatic lobes with engorged vascula- tures and mild hemoperitoneum. A liver biopsy revealed the histopathology of angiosarcoma. The patient suffered multiple organ failure within one month of treatment.Conclusions. Various post-transplant malignancies are not uncommon after transplantation, warranting periodic screenings for any symptoms in these patients.
引用
收藏
页码:1597 / 1600
页数:4
相关论文
共 28 条
[1]   Lower Malignancy Rates in Renal Allograft Recipients Converted to Sirolimus-Based, Calcineurin Inhibitor-Free Immunotherapy: 24-Month Results From the CONVERT Trial [J].
Alberu, Josefina ;
Pascoe, Michael D. ;
Campistol, Josep M. ;
Schena, Francesco P. ;
del Carmen Rial, Maria ;
Polinsky, Martin ;
Neylan, John F. ;
Korth-Bradley, Joan ;
Goldberg-Alberts, Robert ;
Maller, Eric S. .
TRANSPLANTATION, 2011, 92 (03) :303-310
[2]   Angiosarcoma at the site of nonfunctioning arteriovenous fistula in a kidney transplant recipient [J].
Aldaabil, Riyadh A. ;
Alkhunaizi, Ahmed M. ;
Al-Dawsari, Najla A. ;
Dawamneh, Mohamad F. ;
Rabah, Rola .
JOURNAL OF VASCULAR SURGERY CASES AND INNOVATIVE TECHNIQUES, 2016, 2 (02) :53-55
[3]   Sarcomas other than Kaposi sarcoma occurring in immunodeficiency: interpretations from a systematic literature review [J].
Bhatia, Kishor ;
Shiels, Meredith S. ;
Berg, Alexandra ;
Engels, Eric A. .
CURRENT OPINION IN ONCOLOGY, 2012, 24 (05) :537-546
[4]   MALIGNANT VASCULAR TUMORS OF THE LIVER - RADIOLOGIC-PATHOLOGICAL CORRELATION [J].
BUETOW, PC ;
BUCK, JL ;
ROS, PR ;
GOODMAN, ZD .
RADIOGRAPHICS, 1994, 14 (01) :153-166
[5]   Randomized Controlled Trial of Sirolimus for Renal Transplant Recipients at High Risk for Nonmelanoma Skin Cancer [J].
Campbell, S. B. ;
Walker, R. ;
Tai, S. See ;
Jiang, Q. ;
Russ, G. R. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2012, 12 (05) :1146-1156
[6]   Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation [J].
Campistol, Josep M. ;
Eris, Josette ;
Oberbauer, Rainer ;
Friend, Peter ;
Hutchison, Brian ;
Morales, Jose M. ;
Claesson, Kerstin ;
Stallone, Giovanni ;
Russ, Graeme ;
Rostaing, Lionel ;
Kreis, Henri ;
Burke, James T. ;
Brault, Yves ;
Scarola, Joseph A. ;
Neylan, John F. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (02) :581-589
[7]   Primary hepatic angiosarcoma [J].
Chaudhary, P. ;
Bhadana, U. ;
Singh, R. A. K. ;
Ahuja, A. .
EJSO, 2015, 41 (09) :1137-1143
[8]   Hepatocellular carcinoma following renal transplantation: Experience in northern Taiwan [J].
Chiang, Y. J. ;
Wang, H. H. ;
Liu, K. L. ;
Chu, S. H. ;
Lee, W. C. .
TRANSPLANTATION PROCEEDINGS, 2008, 40 (07) :2397-2399
[9]   Spectrum of Cancer Risk Among US Solid Organ Transplant Recipients [J].
Engels, Eric A. ;
Pfeiffer, Ruth M. ;
Fraumeni, Joseph F., Jr. ;
Kasiske, Bertram L. ;
Israni, Ajay K. ;
Snyder, Jon J. ;
Wolfe, Robert A. ;
Goodrich, Nathan P. ;
Bayakly, A. Rana ;
Clarke, Christina A. ;
Copeland, Glenn ;
Finch, Jack L. ;
Fleissner, Mary Lou ;
Goodman, Marc T. ;
Kahn, Amy ;
Koch, Lori ;
Lynch, Charles F. ;
Madeleine, Margaret M. ;
Pawlish, Karen ;
Rao, Chandrika ;
Williams, Melanie A. ;
Castenson, David ;
Curry, Michael ;
Parsons, Ruth ;
Fant, Gregory ;
Lin, Monica .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 306 (17) :1891-1901
[10]   Angiosarcoma: clinical and imaging features from head to toe [J].
Gaballah, Ayman H. ;
Jensen, Corey T. ;
Palmquist, Sarah ;
Pickhardt, Perry J. ;
Duran, Alper ;
Broering, Gregory ;
Elsayes, Khaled M. .
BRITISH JOURNAL OF RADIOLOGY, 2017, 90 (1075)