The innate allergenicity of helminth parasites

被引:24
作者
Falcone, FH
Loukas, A
Quinnell, RJ
Pritchard, DI
机构
[1] Univ Nottingham, Sch Pharm, Immune Modulat Res Grp, Nottingham NG7 2RD, England
[2] Univ Leeds, Sch Biol, Leeds LS2 9JT, W Yorkshire, England
[3] George Washington Univ, Med Ctr, Dept Microbiol & Trop Med, Washington, DC 20037 USA
关键词
helminth; Th2; Necator americanus; superallergen; proteases; lectins;
D O I
10.1385/CRIAI:26:1:61
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Helminth parasites are well known to induce an immune response in their hosts characterised by elevated IgE, peripheral blood or local tissue eosinophilia, and in some cases, intestinal mastocytosis. This immunological response has a strong T-helper 2 (Th2) cytokine bias and is reminescent of the immunological constellation found in allergic diseases. However, the molecular forces driving the Th2 response to helminth parasites are still not understood. By using the human hookworm parasite Necator americanus as an example, the authors of the current article propose that in the course of its life cycle, this parasite becomes innately allergenic through the secretion of a molecular array designed to promote tissue migration and homing, feeding and survival against immunological attack. This complex array comprises proteases, lectins and other classes of molecules. Subsequent immunological and physiological events seemingly protect the host from both the allergic sequelae of exposure to environmental allergens and, moreover, from the parasite itself.
引用
收藏
页码:61 / 72
页数:12
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