Pregnancy late in life: A hospital-based study of birth outcomes

被引:12
作者
Delpisheh, Ali [1 ,2 ]
Brabin, Loretta [3 ]
Attia, Eman [1 ]
Brabin, Bernard J. [1 ,4 ,5 ]
机构
[1] Univ Liverpool Liverpool Sch Trop Med, Child & Reprod Hlth Grp, Pembroke Pl, Liverpool L3 5QA, Merseyside, England
[2] Ilam Univ Med Sci, Dept Community Med, Ilam, Iran
[3] Univ Manchester, Acad Unit Obstet & Gynaecol, Manchester M13 9PL, Lancs, England
[4] Univ Amsterdam, Acad Med Ctr, Emma Kinderziekenhuis, NL-1012 WX Amsterdam, Netherlands
[5] Royal Liverpool Childrens Hosp NHS Trust, Dept Community Child Hlth, Liverpool, Merseyside, England
关键词
D O I
10.1089/jwh.2007.0511
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: Pregnancy in older women is of great relevance, particularly in developed countries where many women experience pregnancy late in the childbearing age. Methods: A hospital-based data analysis of 9506 delivery records from 1998 to 2003 at the Liverpool Women's Hospital was undertaken to assess pregnancy outcomes in older women of reproductive age. Results: Overall, 2.4% of mothers were >40 years of age (advanced), 5.6% were <20 years (adolescents), and 92% were between 20 and 40 years. The prevalence of low birthweight (LBW), preterm birth, and small for gestational age by maternal age category followed a U-shaped curve with nadirs in the middle age classes. The gestational age of older mothers was 1 week shorter than that for women aged 26-30 years (p = 0.005). Primiparaes >40 years were at higher risk for delivering a LBW (9.4% vs. 5.3%, p = 0.005) or a very preterm baby (8.9% vs. 4.4%, p = 0.001) than were multiparous mothers of the same age. There was an association between maternal advanced age and LBW (adjusted OR [AOR], 1.7, 95% CI 1.4-2.5, p = 0.001), preterm birth (AOR 1.4, 95% CI 1.1-2.4, p = 0.04), or very preterm birth (AOR 1.6, 95% CI 1.2-3.5, p = 0.002) after controlling for prenatal alcohol and smoking exposure, household deprivation, maternal anemia, obesity, parity, and single parenthood. Conclusions: Pregnancy in older women is associated with adverse birth outcomes, particularly in primigravidas. Increased health promotion is required to highlight the risk of adverse birth outcomes in women who become pregnant for the first time in the late childbearing years.
引用
收藏
页码:965 / 970
页数:6
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