Increased expression of CD146 and microvessel density (MVD) in invasive micropapillary carcinoma of the breast: Comparative study with invasive ductal carcinoma-not otherwise specified

被引：30
作者：
Li, Weidong [2 ]
Yang, Dongling [1 ]
Wang, Shuling [2 ]
Guo, Xiaojing [2 ]
Lang, Ronggang [2 ]
Fan, Yu [2 ]
Gu, Feng [2 ]
Zhang, Xinmin [3 ]
Niu, Yun [2 ]
Yan, Xiyun [1 ]
Fu, Li [2 ]
机构：
[1] Chinese Acad Sci, Natl Lab Biomacromol, Inst Biophys, Beijing 100101, Peoples R China
[2] Tianjin Med Univ, Canc Inst & Hosp, Dept Breast Canc Pathol & Res Lab, Tianjin 300060, Peoples R China
[3] Temple Univ, Dept Pathol & Lab Med, Sch Med, Philadelphia, PA 19140 USA
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2011年 / 207卷 / 12期
基金：
中国国家自然科学基金;
关键词：
CD; 146; Angiogenesis; Breast IMPC; Microvessel density (MVD); CELL-ADHESION MOLECULES; POOR-PROGNOSIS; TUMOR PROGRESSION; GROWTH-FACTOR; ANGIOGENESIS; CANCER; MARKER; MUC18; MELANOMA; GRADE;
D O I：
10.1016/j.prp.2011.09.009
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Invasive micropapillary carcinoma (IMPC) is a rare variant of ductal carcinoma of the breast, and is characterized by a high metastatic potential and an aggressive clinical course. Studies of CD 146 expression and function in breast cancer remain scarce. The aim of this study was to evaluate the role of CD146 and microvessel density (MVD) in breast IMPC. CD146 mRNA expression and immunohistochemistry for CD146 and MVD measured by CD31 were assessed in 82 cases of IMPC and 137 cases of invasive ductal carcinoma, not otherwise specified (IDC-NOS). The mRNA level of CD146 in cancer specimens was higher in IMPC than in IDC-NOS. CD146 expression in tumor cells was up-regulated in IMPC as compared with that in IDC-NOS, and was positively correlated with histological grade. ER. PR status, and P53 expression in IMPC and IDC-NOS. CD146 expression in vascular endothelial cells was significantly higher than that in IDC, and was positively correlated with tumor progression in IMPC and IDC-NOS. MVD in IMPC was significantly higher than that in IDC. CD146 expression in tumor cells was positively correlated with that in vascular endothelial cells of IMPC and IDC-NOS. The association of CD146 expression with MVD and its correlation with progression in breast carcinoma indicated that CD146 is a potentially useful prognostic marker for breast cancer. CD146 could be a new drug target in the treatment of breast cancer. (C) 2011 Elsevier GmbH. All rights reserved.
引用
收藏
页码：739 / 746
页数：8
相关论文
共 34 条
[1]   M-cam expression as marker of poor prognosis in epithelial ovarian cancer [J].
Aldovini, Daniela ;
Demichelis, Francesca ;
Doglioni, Claudio ;
Di Vizio, Dolores ;
Galligioni, Enzo ;
Brugnara, Sonia ;
Zeni, Bruna ;
Griso, Claudia ;
Pegoraro, Cristina ;
Zannoni, Marina ;
Gariboldi, Manuela ;
Balladore, Emanuela ;
Mezzanzanica, Delia ;
Canevari, Silvana ;
Barbareschi, Mattia .
INTERNATIONAL JOURNAL OF CANCER, 2006, 119 (08) :1920-1926
[2]   Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease [J].
Bluff, J. E. ;
Menakuru, S. R. ;
Cross, S. S. ;
Higham, S. E. ;
Balasubramanian, S. P. ;
Brown, N. J. ;
Reed, M. W. ;
Staton, C. A. .
BRITISH JOURNAL OF CANCER, 2009, 101 (04) :666-672
[3]   Angiogenesis in cancer and other diseases [J].
Carmeliet, P ;
Jain, RK .
NATURE, 2000, 407 (6801) :249-257
[4]  
Carpenter P.M., 2009, INT J SURG PATHOL
[5]   Breast carcinoma with micropapillary features: Clinicopathologic study and long-term follow-up of 100 cases [J].
Chen, Ling ;
Fan, Yu ;
Lang, Rong-gang ;
Guo, Xiao-jing ;
Sun, Yu-lan ;
Cui, Li-fang ;
Liu, Fang-fang ;
Wei, Jia ;
Zhang, Xin-min ;
Fu, Li .
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2008, 16 (02) :155-163
[6]   PATHOLOGICAL PROGNOSTIC FACTORS IN BREAST-CANCER .1. THE VALUE OF HISTOLOGICAL GRADE IN BREAST-CANCER - EXPERIENCE FROM A LARGE STUDY WITH LONG-TERM FOLLOW-UP [J].
ELSTON, CW ;
ELLIS, IO .
HISTOPATHOLOGY, 1991, 19 (05) :403-410
[7]   Microvessel and lymphatic density in tubular carcinoma of the breast:: Comparative study with invasive low-grade ductal carcinoma [J].
Fernandez-Aguilar, Sergio ;
Jondet, Michel ;
Simonart, Thierry ;
Noel, Jean-Christophe .
BREAST, 2006, 15 (06) :782-785
[8]   ANGIOGENESIS IN CANCER, VASCULAR, RHEUMATOID AND OTHER DISEASE [J].
FOLKMAN, J .
NATURE MEDICINE, 1995, 1 (01) :27-31
[9]   Poor prognosis in breast carcinomas correlates with increased expression of targetable CD146 and c-Met and with proteomic basal-like phenotype [J].
Garcia, Stephane ;
Dales, Jean-Philippe ;
Charafe-Jauffret, Emmanuelle ;
Carpentier-Meunier, Severine ;
Andrac-Meyer, Lucile ;
Jacquemier, Jocelyne ;
Andonian, Claudine ;
Lavaut, Marie-Noelle ;
Allasia, Claude ;
Bonnier, Pascal ;
Charpin, Colette .
HUMAN PATHOLOGY, 2007, 38 (06) :830-841
[10]   Expression of cell adhesion molecules, CD44s and E-cadherin, and microvessel density in invasive micropapillary carcinoma of the breast [J].
Gong, Y ;
Sun, X ;
Huo, L ;
Wiley, EL ;
Rao, MS .
HISTOPATHOLOGY, 2005, 46 (01) :24-30
1234