共 184 条
Continuous flow chemistry: where are we now? Recent applications, challenges and limitations
被引:202
作者:

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Watts, Paul
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Nelson Mandela Univ, ZA-6031 Port Elizabeth, South Africa Nelson Mandela Univ, ZA-6031 Port Elizabeth, South Africa
机构:
[1] Nelson Mandela Univ, ZA-6031 Port Elizabeth, South Africa
关键词:
LIFE-CYCLE ASSESSMENT;
IN-SITU GENERATION;
SCALE-UP;
ORGANIC-SYNTHESIS;
MASS-TRANSFER;
GAS-LIQUID;
PROCESS INTENSIFICATION;
CONTINUOUS PURIFICATION;
CHEMICAL-SYNTHESIS;
ASSISTED SYNTHESIS;
D O I:
10.1039/c8cc07427e
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
A general outlook of the changing face of chemical synthesis is provided in this article through recent applications of continuous flow processing in both industry and academia. The benefits, major challenges and limitations associated with the use of this mode of processing are also given due attention as an attempt to put into perspective the current position of continuous flow processing, either as an alternative or potential combinatory technology for batch processing.
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页码:13894 / 13928
页数:35
相关论文
共 184 条
[1]
Advances in steady-state continuous-flow purification by small-scale free-flow electrophoresis
[J].
Agostino, Fletcher J.
;
Krylov, Sergey N.
.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY,
2015, 72
:68-79

Agostino, Fletcher J.
论文数: 0 引用数: 0
h-index: 0
机构:
York Univ, Ctr Res Biomol Interact, Toronto, ON M3J 2R7, Canada York Univ, Ctr Res Biomol Interact, Toronto, ON M3J 2R7, Canada

Krylov, Sergey N.
论文数: 0 引用数: 0
h-index: 0
机构:
York Univ, Ctr Res Biomol Interact, Toronto, ON M3J 2R7, Canada York Univ, Ctr Res Biomol Interact, Toronto, ON M3J 2R7, Canada
[2]
The in situ generation and reactive quench of diazonium compounds in the synthesis of azo compounds in microreactors
[J].
Akwi, Faith M.
;
Watts, Paul
.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,
2016, 12
:1987-2004

Akwi, Faith M.
论文数: 0 引用数: 0
h-index: 0
机构:
Nelson Mandela Metropolitan Univ, Univ Way, ZA-6031 Port Elizabeth, South Africa Nelson Mandela Metropolitan Univ, Univ Way, ZA-6031 Port Elizabeth, South Africa

Watts, Paul
论文数: 0 引用数: 0
h-index: 0
机构:
Nelson Mandela Metropolitan Univ, Univ Way, ZA-6031 Port Elizabeth, South Africa Nelson Mandela Metropolitan Univ, Univ Way, ZA-6031 Port Elizabeth, South Africa
[3]
Enabling the Scale-Up of a Key Asymmetric Hydrogenation Step in the Synthesis of an API Using Continuous Flow Solid-Supported Catalysis
[J].
Amara, Zacharias
;
Poliakoff, Martyn
;
Duque, Ruben
;
Geier, Daniel
;
Francio, Giancarlo
;
Gordon, Charles M.
;
Meadows, Rebecca E.
;
Woodward, Robert
;
Leitner, Walter
.
ORGANIC PROCESS RESEARCH & DEVELOPMENT,
2016, 20 (07)
:1321-1327

Amara, Zacharias
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

论文数: 引用数:
h-index:
机构:

Duque, Ruben
论文数: 0 引用数: 0
h-index: 0
机构:
Rhein Westfal TH Aachen, ITMC, Worringerweg 2, D-52074 Aachen, Germany Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

Geier, Daniel
论文数: 0 引用数: 0
h-index: 0
机构:
Rhein Westfal TH Aachen, ITMC, Worringerweg 2, D-52074 Aachen, Germany Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

Francio, Giancarlo
论文数: 0 引用数: 0
h-index: 0
机构:
Rhein Westfal TH Aachen, ITMC, Worringerweg 2, D-52074 Aachen, Germany Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

Gordon, Charles M.
论文数: 0 引用数: 0
h-index: 0
机构:
Britest Ltd, Heath Business & Tech Pk, Runcorn WA7 4QX, Cheshire, England Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

Meadows, Rebecca E.
论文数: 0 引用数: 0
h-index: 0
机构:
AstraZeneca, Pharmaceut Dev, Silk Rd Business Pk, Macclesfield SK10 2NA, Cheshire, England Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

Woodward, Robert
论文数: 0 引用数: 0
h-index: 0
机构:
AstraZeneca, Pharmaceut Dev, Silk Rd Business Pk, Macclesfield SK10 2NA, Cheshire, England Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

Leitner, Walter
论文数: 0 引用数: 0
h-index: 0
机构:
Rhein Westfal TH Aachen, ITMC, Worringerweg 2, D-52074 Aachen, Germany Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
[4]
Continuous Flow Synthesis of Chiral Amines in Organic Solvents: Immobilization of E. coli Cells Containing Both ω-Transaminase and PLP
[J].
Andrade, Leandro H.
;
Kroutil, Wolfgang
;
Jamison, Timothy F.
.
ORGANIC LETTERS,
2014, 16 (23)
:6092-6095

Andrade, Leandro H.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Chem, Cambridge, MA 02139 USA MIT, Dept Chem, Cambridge, MA 02139 USA

论文数: 引用数:
h-index:
机构:

Jamison, Timothy F.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Chem, Cambridge, MA 02139 USA MIT, Dept Chem, Cambridge, MA 02139 USA
[5]
Noninvasive Sensor for the Detection of Process Parameters for Multiphase Slug Flows in Microchannels
[J].
Antweiler, Nicolai
;
Gatberg, Sascha
;
Jestel, Guenther
;
Franzke, Joachim
;
Agar, David W.
.
ACS SENSORS,
2016, 1 (09)
:1117-1123

Antweiler, Nicolai
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Dortmund, Lab Chem React Engn, Dept Biochem & Chem Engn, D-44227 Dortmund, Germany Tech Univ Dortmund, Lab Chem React Engn, Dept Biochem & Chem Engn, D-44227 Dortmund, Germany

Gatberg, Sascha
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Dortmund, Lab Chem React Engn, Dept Biochem & Chem Engn, D-44227 Dortmund, Germany Tech Univ Dortmund, Lab Chem React Engn, Dept Biochem & Chem Engn, D-44227 Dortmund, Germany

Jestel, Guenther
论文数: 0 引用数: 0
h-index: 0
机构:
Leibniz Inst Analyt Wissensch ISAS eV, D-44139 Dortmund, Germany Tech Univ Dortmund, Lab Chem React Engn, Dept Biochem & Chem Engn, D-44227 Dortmund, Germany

论文数: 引用数:
h-index:
机构:

Agar, David W.
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Dortmund, Lab Chem React Engn, Dept Biochem & Chem Engn, D-44227 Dortmund, Germany Tech Univ Dortmund, Lab Chem React Engn, Dept Biochem & Chem Engn, D-44227 Dortmund, Germany
[6]
A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations
[J].
Archambault, Cynthia M.
;
Leadbeater, Nicholas E.
.
RSC ADVANCES,
2016, 6 (103)
:101171-101177

Archambault, Cynthia M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Connecticut, Dept Chem, 55 North Eagleville Rd, Storrs, CT 06269 USA Univ Connecticut, Dept Chem, 55 North Eagleville Rd, Storrs, CT 06269 USA

Leadbeater, Nicholas E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Connecticut, Dept Chem, 55 North Eagleville Rd, Storrs, CT 06269 USA Univ Connecticut, Dept Chem, 55 North Eagleville Rd, Storrs, CT 06269 USA
[7]
Batch and Continuous-Flow One-Pot Processes using Amine Diazotization to Produce Silylated Diazo Reagents
[J].
Audubert, Clement
;
Marin, Oscar Javier Gamboa
;
Lebel, Helene
.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,
2017, 56 (22)
:6294-6297

Audubert, Clement
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montreal, Dept Chim, Montreal, PQ, Canada Univ Montreal, Dept Chim, Montreal, PQ, Canada

Marin, Oscar Javier Gamboa
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montreal, Dept Chim, Montreal, PQ, Canada Univ Montreal, Dept Chim, Montreal, PQ, Canada

Lebel, Helene
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montreal, Dept Chim, Montreal, PQ, Canada Univ Montreal, Dept Chim, Montreal, PQ, Canada
[8]
Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning
[J].
Balogh, Attila
;
Domokos, Andras
;
Farkas, Balazs
;
Farkas, Attila
;
Rapi, Zsolt
;
Kiss, Domokos
;
Nyiri, Zoltan
;
Eke, Zsuzsanna
;
Szarka, Gyorgyi
;
Orkenyi, Robert
;
Matravolgyi, Bela
;
Faigl, Ferenc
;
Marosi, Gyorgy
;
Nagy, Zsombor Kristof
.
CHEMICAL ENGINEERING JOURNAL,
2018, 350
:290-299

Balogh, Attila
论文数: 0 引用数: 0
h-index: 0
机构:
Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Domokos, Andras
论文数: 0 引用数: 0
h-index: 0
机构:
Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Farkas, Balazs
论文数: 0 引用数: 0
h-index: 0
机构:
Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Farkas, Attila
论文数: 0 引用数: 0
h-index: 0
机构:
Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Rapi, Zsolt
论文数: 0 引用数: 0
h-index: 0
机构:
Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Kiss, Domokos
论文数: 0 引用数: 0
h-index: 0
机构:
Budapest Univ Technol & Econ, Dept Automat & Appl Informat, H-1117 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Nyiri, Zoltan
论文数: 0 引用数: 0
h-index: 0
机构:
Eotvos Lorand Univ, Joint Res & Training Lab Separat Tech, H-1117 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Eke, Zsuzsanna
论文数: 0 引用数: 0
h-index: 0
机构:
Eotvos Lorand Univ, Joint Res & Training Lab Separat Tech, H-1117 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Szarka, Gyorgyi
论文数: 0 引用数: 0
h-index: 0
机构:
Hungarian Acad, Res Ctr Nat Sci, Polymer Chem Res Grp, H-1117 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Orkenyi, Robert
论文数: 0 引用数: 0
h-index: 0
机构:
Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Matravolgyi, Bela
论文数: 0 引用数: 0
h-index: 0
机构:
Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Faigl, Ferenc
论文数: 0 引用数: 0
h-index: 0
机构:
Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Marosi, Gyorgy
论文数: 0 引用数: 0
h-index: 0
机构:
Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

Nagy, Zsombor Kristof
论文数: 0 引用数: 0
h-index: 0
机构:
Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary
[9]
Preparation of vinyl ethers using a Wittig approach, and their subsequent hydrogenation employing continuous-flow processing
[J].
Balti, Monaem
;
Efrit, Mohamed Lotfi
;
Leadbeater, Nicholas E.
.
TETRAHEDRON LETTERS,
2016, 57 (16)
:1804-1806

Balti, Monaem
论文数: 0 引用数: 0
h-index: 0
机构:
Univ El Manar, Lab Organ Synth & Heterocycl Chem, Fac Sci Tunis, Dept Chem, Tunis, Tunisia Univ El Manar, Lab Organ Synth & Heterocycl Chem, Fac Sci Tunis, Dept Chem, Tunis, Tunisia

Efrit, Mohamed Lotfi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ El Manar, Lab Organ Synth & Heterocycl Chem, Fac Sci Tunis, Dept Chem, Tunis, Tunisia Univ El Manar, Lab Organ Synth & Heterocycl Chem, Fac Sci Tunis, Dept Chem, Tunis, Tunisia

Leadbeater, Nicholas E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Connecticut, Dept Chem, 55 North Eagleville Rd, Storrs, CT 06269 USA Univ El Manar, Lab Organ Synth & Heterocycl Chem, Fac Sci Tunis, Dept Chem, Tunis, Tunisia
[10]
Rapid flow-based synthesis of poly(3-hexylthiophene) using 2-methyltetrahydrofuran as a bio-derived reaction solvent
[J].
Bannock, James E.
;
Xu, Wenmin
;
Baissas, Theophile
;
Heeney, Martin
;
de Mello, John C.
.
EUROPEAN POLYMER JOURNAL,
2016, 80
:240-246

Bannock, James E.
论文数: 0 引用数: 0
h-index: 0
机构:
Imperial Coll London, Ctr Plast Elect, Exhibit Rd, London SW7 2AZ, England Imperial Coll London, Ctr Plast Elect, Exhibit Rd, London SW7 2AZ, England

Xu, Wenmin
论文数: 0 引用数: 0
h-index: 0
机构: Imperial Coll London, Ctr Plast Elect, Exhibit Rd, London SW7 2AZ, England

Baissas, Theophile
论文数: 0 引用数: 0
h-index: 0
机构: Imperial Coll London, Ctr Plast Elect, Exhibit Rd, London SW7 2AZ, England

Heeney, Martin
论文数: 0 引用数: 0
h-index: 0
机构: Imperial Coll London, Ctr Plast Elect, Exhibit Rd, London SW7 2AZ, England

de Mello, John C.
论文数: 0 引用数: 0
h-index: 0
机构: Imperial Coll London, Ctr Plast Elect, Exhibit Rd, London SW7 2AZ, England