Continuous flow chemistry: where are we now? Recent applications, challenges and limitations

被引:202
作者
Akwi, Faith M. [1 ]
Watts, Paul [1 ]
机构
[1] Nelson Mandela Univ, ZA-6031 Port Elizabeth, South Africa
关键词
LIFE-CYCLE ASSESSMENT; IN-SITU GENERATION; SCALE-UP; ORGANIC-SYNTHESIS; MASS-TRANSFER; GAS-LIQUID; PROCESS INTENSIFICATION; CONTINUOUS PURIFICATION; CHEMICAL-SYNTHESIS; ASSISTED SYNTHESIS;
D O I
10.1039/c8cc07427e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A general outlook of the changing face of chemical synthesis is provided in this article through recent applications of continuous flow processing in both industry and academia. The benefits, major challenges and limitations associated with the use of this mode of processing are also given due attention as an attempt to put into perspective the current position of continuous flow processing, either as an alternative or potential combinatory technology for batch processing.
引用
收藏
页码:13894 / 13928
页数:35
相关论文
共 184 条
[1]   Advances in steady-state continuous-flow purification by small-scale free-flow electrophoresis [J].
Agostino, Fletcher J. ;
Krylov, Sergey N. .
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2015, 72 :68-79
[2]   The in situ generation and reactive quench of diazonium compounds in the synthesis of azo compounds in microreactors [J].
Akwi, Faith M. ;
Watts, Paul .
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2016, 12 :1987-2004
[3]   Enabling the Scale-Up of a Key Asymmetric Hydrogenation Step in the Synthesis of an API Using Continuous Flow Solid-Supported Catalysis [J].
Amara, Zacharias ;
Poliakoff, Martyn ;
Duque, Ruben ;
Geier, Daniel ;
Francio, Giancarlo ;
Gordon, Charles M. ;
Meadows, Rebecca E. ;
Woodward, Robert ;
Leitner, Walter .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2016, 20 (07) :1321-1327
[4]   Continuous Flow Synthesis of Chiral Amines in Organic Solvents: Immobilization of E. coli Cells Containing Both ω-Transaminase and PLP [J].
Andrade, Leandro H. ;
Kroutil, Wolfgang ;
Jamison, Timothy F. .
ORGANIC LETTERS, 2014, 16 (23) :6092-6095
[5]   Noninvasive Sensor for the Detection of Process Parameters for Multiphase Slug Flows in Microchannels [J].
Antweiler, Nicolai ;
Gatberg, Sascha ;
Jestel, Guenther ;
Franzke, Joachim ;
Agar, David W. .
ACS SENSORS, 2016, 1 (09) :1117-1123
[6]   A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations [J].
Archambault, Cynthia M. ;
Leadbeater, Nicholas E. .
RSC ADVANCES, 2016, 6 (103) :101171-101177
[7]   Batch and Continuous-Flow One-Pot Processes using Amine Diazotization to Produce Silylated Diazo Reagents [J].
Audubert, Clement ;
Marin, Oscar Javier Gamboa ;
Lebel, Helene .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (22) :6294-6297
[8]   Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning [J].
Balogh, Attila ;
Domokos, Andras ;
Farkas, Balazs ;
Farkas, Attila ;
Rapi, Zsolt ;
Kiss, Domokos ;
Nyiri, Zoltan ;
Eke, Zsuzsanna ;
Szarka, Gyorgyi ;
Orkenyi, Robert ;
Matravolgyi, Bela ;
Faigl, Ferenc ;
Marosi, Gyorgy ;
Nagy, Zsombor Kristof .
CHEMICAL ENGINEERING JOURNAL, 2018, 350 :290-299
[9]   Preparation of vinyl ethers using a Wittig approach, and their subsequent hydrogenation employing continuous-flow processing [J].
Balti, Monaem ;
Efrit, Mohamed Lotfi ;
Leadbeater, Nicholas E. .
TETRAHEDRON LETTERS, 2016, 57 (16) :1804-1806
[10]   Rapid flow-based synthesis of poly(3-hexylthiophene) using 2-methyltetrahydrofuran as a bio-derived reaction solvent [J].
Bannock, James E. ;
Xu, Wenmin ;
Baissas, Theophile ;
Heeney, Martin ;
de Mello, John C. .
EUROPEAN POLYMER JOURNAL, 2016, 80 :240-246