Annexins:: Linking Ca2+ signalling to membrane dynamics

被引：1167
作者：
Gerke, V [1 ]
Creutz, CE
Moss, SE
机构：
[1] Univ Munster, Ctr Mol Biol Inflammat, Inst Med Biochem, D-4400 Munster, Germany
[2] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA
[3] Inst Ophthalmol, Div Cell Biol, London EC1V 9EL, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 06期
基金：
英国惠康基金;
关键词：
D O I：
10.1038/nrm1661
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Eukaryotic cells contain various Ca2+-effector proteins that mediate cellular responses to changes in intracellular Ca2+ levels. A unique class of these proteins - annexins - can bind to certain membrane phospholipids in a Ca2+-dependent manner, providing a link between Ca2+ signalling and membrane functions. By forming networks on the membrane surface, annexins can function as organizers of membrane domains and membrane-recruitment platforms for proteins with which they interact. These and related properties enable annexins to participate in several otherwise unrelated events that range from membrane dynamics to cell differentiation and migration.
引用
收藏
页码：449 / 461
页数：13
相关论文
共 130 条
  • [1] A ROLE FOR CALPACTIN IN CALCIUM-DEPENDENT EXOCYTOSIS IN ADRENAL CHROMAFFIN CELLS
    ALI, SM
    GEISOW, MJ
    BURGOYNE, RD
    [J]. NATURE, 1989, 340 (6231) : 313 - 315
  • [2] Annexin I is an endogenous ligand that mediates apoptotic cell engulfment
    Arur, S
    Uche, UE
    Rezaul, K
    Fong, M
    Scranton, V
    Cowan, AE
    Mohler, W
    Han, DK
    [J]. DEVELOPMENTAL CELL, 2003, 4 (04) : 587 - 598
  • [3] Crystal structure of bovine annexin VI in a calcium-bound state
    Avila-Sakar, AJ
    Creutz, CE
    Kretsinger, RH
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1998, 1387 (1-2): : 103 - 116
  • [4] Membrane-bound 3D structures reveal the intrinsic flexibility of annexin VI
    Avila-Sakar, AJ
    Kretsinger, RH
    Creutz, CE
    [J]. JOURNAL OF STRUCTURAL BIOLOGY, 2000, 130 (01) : 54 - 62
  • [5] Annexins in cell membrane dynamics:: Ca2+-regulated association of lipid microdomains
    Babiychuk, EB
    Draeger, A
    [J]. JOURNAL OF CELL BIOLOGY, 2000, 150 (05) : 1113 - 1123
  • [6] Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
    Bache, KG
    Brech, A
    Mehlum, A
    Stenmark, H
    [J]. JOURNAL OF CELL BIOLOGY, 2003, 162 (03) : 435 - 442
  • [7] STRUCTURE-FUNCTION ANALYSIS OF THE ION-CHANNEL SELECTIVITY FILTER IN HUMAN ANNEXIN-V
    BERENDES, R
    VOGES, D
    DEMANGE, P
    HUBER, R
    BURGER, A
    [J]. SCIENCE, 1993, 262 (5132) : 427 - 430
  • [8] The crystal structure and ion channel activity of human Annexin II, a peripheral membrane protein
    Burger, A
    Berendes, R
    Liemann, S
    Benz, J
    Hofmann, A
    Gottig, P
    Huber, R
    Gerke, V
    Thiel, C
    Romisch, J
    Weber, K
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1996, 257 (04) : 839 - 847
  • [9] Evidence for a role of the adenosine 5′-triphosphate-binding cassette transporter A1 in the externalization of annexin I from pituitary folliculo-stellate cells
    Chapman, LP
    Epton, MJ
    Buckingham, JC
    Morris, JF
    Christian, HC
    [J]. ENDOCRINOLOGY, 2003, 144 (03) : 1062 - 1073
  • [10] Annexin II in exocytosis: Catecholamine secretion requires the translocation of p36 to the subplasmalemmal region in chromaffin cells
    ChasserotGolaz, S
    Vitale, N
    Sagot, I
    Delouche, B
    Dirrig, S
    Pradel, LA
    Henry, JP
    Aunis, D
    Bader, MF
    [J]. JOURNAL OF CELL BIOLOGY, 1996, 133 (06) : 1217 - 1236
12345678910