Annexins:: Linking Ca2+ signalling to membrane dynamics

被引：1184

作者：

Gerke, V ^{[1
]}

Creutz, CE

Moss, SE

机构：

[1] Univ Munster, Ctr Mol Biol Inflammat, Inst Med Biochem, D-4400 Munster, Germany

[2] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA

[3] Inst Ophthalmol, Div Cell Biol, London EC1V 9EL, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrm1661

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotic cells contain various Ca2+-effector proteins that mediate cellular responses to changes in intracellular Ca2+ levels. A unique class of these proteins - annexins - can bind to certain membrane phospholipids in a Ca2+-dependent manner, providing a link between Ca2+ signalling and membrane functions. By forming networks on the membrane surface, annexins can function as organizers of membrane domains and membrane-recruitment platforms for proteins with which they interact. These and related properties enable annexins to participate in several otherwise unrelated events that range from membrane dynamics to cell differentiation and migration.

引用

页码：449 / 461

页数：13

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