Demyelinating Neuropathy Due to Intravascular Large B-cell Lymphoma

被引：7

作者：

Fukami, Yuki ^{[1
]}

Koike, Haruki ^{[1
]}

Iijima, Masahiro ^{[1
,2
]}

Hagita, Junichirou ^{[3
]}

Niwa, Hisayoshi ^{[4
]}

Nishi, Ryoji ^{[1
]}

Kawagashira, Yuichi ^{[1
]}

Katsuno, Masahisa ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Neurol, Nagoya, Aichi, Japan

[2] Nagoya Univ Hosp, Ctr Adv Med & Clin Res, Dept Adv Med, Nagoya, Aichi, Japan

[3] Kariya Toyota Gen Hosp, Dept Internal Med, Kariya, Aichi, Japan

[4] Kariya Toyota Gen Hosp, Dept Neurol, Kariya, Aichi, Japan

来源：

INTERNAL MEDICINE | 2020年 / 59卷 / 03期

关键词：

demyelinating neuropathy; intravascular large B-cell lymphoma; sural nerve biopsy; onion-bulb formation; AXONAL FEATURES; DISEASE;

D O I：

10.2169/internalmedicine.3228-19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report the case of a 67-year-old man who presented with the acute onset of limb weakness. Brain magnetic resonance imaging revealed multiple abnormal-signal-intensity lesions. Steroids were administered. and the patient initially responded. Nerve conduction testing findings were consistent with demyelinating polyneuropathy. A sural nerve biopsy specimen revealed fascicles with extensive onion-bulb formation. Although skin and sural nerve biopsies showed no atypical cellular infiltration, the histopathological diagnosis of intravascular large B-cell lymphoma was obtained by a brain biopsy. The neuropathy in this patient may be attributed to a demyelinating process independent of ischemic damage by lymphoma.

引用

页码：435 / 438

页数：4

共 13 条

[1] GLASS J, 1993, CANCER-AM CANCER SOC, V71, P3156, DOI 10.1002/1097-0142(19930515)71:10<3156::AID-CNCR2820711043>3.0.CO
[2] 2-O
[3] Griggs JJ, 1997, AM J HEMATOL, V54, P332, DOI 10.1002/(SICI)1096-8652(199704)54:4<332::AID-AJH14>3.0.CO
[4] 2-D
[5] Demyelinating and axonal features of Charcot-Marie-Tooth disease with mutations of myelin-related proteins (PMP22, MPZ and Cx32): a clinicopathological study of 205 Japanese patients
Hattori, N
Yamamoto, M
Yoshihara, T
Koike, H
Nakagawa, M
Yoshikawa, H
Ohnishi, A
Hayasaka, K
Onodera, O
Baba, M
Yasuda, H
Saito, T
Nakashima, K
Kira, J
Kaji, R
Oka, N
Sobue, G
[J]. BRAIN, 2003, 126 : 134 - 151
[6] Lymphoma and peripheral neuropathy: A clinical review
Kelly, JJ
Karcher, DS
[J]. MUSCLE & NERVE, 2005, 31 (03) : 301 - 313
[7] Age associated axonal features in HNPP with 17p11.2 deletion in Japan
Koike, H
Hirayama, M
Yamamoto, M
Ito, H
Hattori, N
Umehara, F
Arimura, K
Ikeda, S
Ando, Y
Nakazato, M
Kaji, R
Hayasaka, K
Nakagawa, M
Sakoda, S
Matsumura, K
Onodera, O
Baba, M
Yasuda, H
Saito, T
Kira, J
Nakashima, K
Oka, N
Sobue, G
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2005, 76 (08) : 1109 - 1114
[8] Ultrastructural mechanisms of macrophage-induced demyelination in CIDP
Koike, Haruki
Nishi, Ryoji
Ikeda, Shohei
Kawagashira, Yuichi
Iijima, Masahiro
Katsuno, Masahisa
Sobue, Gen
[J]. NEUROLOGY, 2018, 91 (23) : 1051 - 1060
[9] Paraneoplastic neuropathy: wide-ranging clinicopathological manifestations
Koike, Haruki
Tanaka, Fumiaki
Sobue, Gen
[J]. CURRENT OPINION IN NEUROLOGY, 2011, 24 (05) : 504 - 510
[10] Lynch Karen M, 2012, J Clin Neuromuscul Dis, V14, P17, DOI 10.1097/CND.0b013e318262ab5c

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