Contrast-Enhanced Ultrasonography: Review and Applications

被引:31
作者
Ajmal, Sania [1 ]
机构
[1] Ascens Genesys Hosp, Dept Radiol, Grand Blanc, MI 48439 USA
关键词
interventional sonography; microbubbles`; therapeutics in ultrasound; sonography; contrast-enhanced ultrasound; ULTRASOUND; MICROBUBBLES; DELIVERY; DRUG; US;
D O I
10.7759/cureus.18243
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Contrast-enhanced ultrasound (CEUS) has revolutionized ultrasound imaging adding enhanced diagnostic imaging and therapeutic applications to its repertoire. CEUS involves the use of microbubbles which are lauded for their benefit of enhanced imaging without the limitations of radiation exposure or risk of nephrotoxicity seen with other contrast agents. In addition, many innovative uses of microbubbles in diagnosis and treatment stages have been discovered. This article summarizes the composition and resonance properties of microbubbles as the contrast agents for ultrasound, as well as their advanced uses in medicine. The basic role of CEUS is in enhancing the imaging of vessels on a macro and micro level to better classify pathological lesions like atherosclerosis. CEUS is also used in identifying tumor lesions by observing for angiogenesis and monitoring tumors post treatment for remission and relapses. Recent research on using microbubbles for focused drug delivery is very promising. Microbubbles can be used for thrombolysis and targeted delivery of chemotherapeutics in an efficient targeted manner while limiting systemic side effects. CEUS can also be used with therapeutic and diagnostic agents to penetrate into the brain allowing better assessment and management of neurodegenerative disorders. In conclusion, the use of microbubbles opens new frontiers in diagnosis and treatment and will likely be a key technique in medicine in the near future.
引用
收藏
页数:5
相关论文
共 13 条
[1]   How to perform Contrast-Enhanced Ultrasound (CEUS) [J].
Dietrich, Christoph F. ;
Averkiou, Michalakis ;
Nielsen, Michael Bachmann ;
Barr, Richard G. ;
Burns, Peter N. ;
Calliada, Fabrizio ;
Cantisani, Vito ;
Choi, Byung ;
Chammas, Maria C. ;
Clevert, Dirk-Andre ;
Claudon, Michel ;
Correas, Jean-Michel ;
Cui, Xin-Wu ;
Cosgrove, David ;
D'Onofrio, Mirko ;
Dong, Yi ;
Eisenbrey, John R. ;
Fontanilla, Teresa ;
Gilja, Odd Helge ;
Ignee, Andre ;
Jenssen, Christian ;
Kono, Yuko ;
Kudo, Masatoshi ;
Lassau, Nathalie ;
Lyshchik, Andrej ;
Meloni, Maria Franca ;
Moriyasu, Fuminori ;
Nolsoe, Christian ;
Piscaglia, Fabio ;
Radzina, Maija ;
Saftoiu, Adrian ;
Sidhu, Paul S. ;
Sporea, Ioan ;
Schreiber-Dietrich, Dagmar ;
Sirlin, Claude B. ;
Stanczak, Maria ;
Weskott, Hans-Peter ;
Wilson, Stephanie R. ;
Willmann, Juergen Karl ;
Kim, Tae Kyoung ;
Jang, Hyun-Jung ;
Vezeridis, Alexandar ;
Westerway, Sue .
ULTRASOUND INTERNATIONAL OPEN, 2018, 4 (01) :E2-E15
[2]  
Gramiak R, 1968, Invest Radiol, V3, P356
[3]   Microbubbles in ultrasound-triggered drug and gene delivery [J].
Hernot, Sophie ;
Klibanov, Alexander L. .
ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (10) :1153-1166
[4]   Construction of thrombus-targeted microbubbles carrying tissue plasminogen activator and their in vitro thrombolysis efficacy: a primary research [J].
Hua, Xing ;
Liu, Ping ;
Gao, Yun-Hua ;
Tan, Kai-Bin ;
Zhou, Li-Na ;
Liu, Zheng ;
Li, Xin ;
Zhou, Shi-Wen ;
Gao, Yue-Juan .
JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2010, 30 (01) :29-35
[5]   Contrast-enhanced US-guided Interventions: Improving Success Rate and Avoiding Complications Using US Contrast Agents1 [J].
Huang, Dean Y. ;
Yusuf, Gibran T. ;
Daneshi, Mohammad ;
Husainy, Mohammad Ali ;
Ramnarine, Raymond ;
Sellars, Maria E. K. ;
Sidhu, Paul S. .
RADIOGRAPHICS, 2017, 37 (02) :652-664
[6]   Enhancing Ablation Effects of a Microbubble-Enhancing Contrast Agent ("SonoVue") in the Treatment of Uterine Fibroids With High-Intensity Focused Ultrasound: A Randomized Controlled Trial [J].
Jiang, Nan ;
Xie, Bin ;
Zhang, Xin ;
He, Min ;
Li, Kequan ;
Bai, Jin ;
Wang, Zhibiao ;
He, Jia ;
Zhang, Lian .
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2014, 37 (05) :1321-1328
[7]   Delivery of drugs with ultrasound [J].
Lindner, JR ;
Kaul, S .
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 2001, 18 (04) :329-337
[8]   Contrast-enhanced US for the Interventional Radiologist: Current and Emerging Applications [J].
Malone, Christopher D. ;
Fetzer, David T. ;
Monsky, Wayne L. ;
Itani, Malak ;
Mellnick, Vincent M. ;
Velez, Philip A. ;
Middleton, William D. ;
Averkiou, Michalakis A. ;
Ramaswamy, Raja S. .
RADIOGRAPHICS, 2020, 40 (02) :562-588
[9]  
Rumack CarolM., 2011, Diagnostic Ultrasound, VForth
[10]   Ultrasound Imaging for Risk Assessment in Atherosclerosis [J].
Steinl, David C. ;
Kaufmann, Beat A. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (05) :9749-9769