Notch signals control the fate of immature progenitor cells in the intestine

被引：726

作者：

Fre, S

Huyghe, M

Mourikis, P

Robine, S

Louvard, D

Artavanis-Tsakonas, S ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Canc Ctr,Dept Cell Biol, Charlestown, MA 02129 USA

[2] Inst Curie, CNRS, F-75231 Paris, France

[3] Univ Paris 11, Fac Sci Orsay, F-91405 Orsay, France

[4] Coll France, F-75231 Paris, France

来源：

NATURE | 2005年 / 435卷 / 7044期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature03589

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Notch signalling pathway plays a crucial role in specifying cellular fates in metazoan development by regulating communication between adjacent cells(1,2). Correlative studies suggested an involvement of Notch in intestinal development. Here, by modulating Notch activity in the mouse intestine, we directly implicate Notch signals in intestinal cell lineage specification. We also show that Notch activation is capable of amplifying the intestinal progenitor pool while inhibiting cell differentiation. We conclude that Notch activity is required for the maintenance of proliferating crypt cells in the intestinal epithelium.

引用

页码：964 / 968

页数：5

共 30 条

[1] Notch signaling: Cell fate control and signal integration in development [J].