On the meaning of the word 'epimutation'

被引：57

作者：

Oey, H. ^{[1
]}

Whitelaw, E. ^{[1
]}

机构：

[1] La Trobe Inst Mol Sci, Melbourne, Vic 3086, Australia

来源：

TRENDS IN GENETICS | 2014年 / 30卷 / 12期

关键词：

D O I：

10.1016/j.tig.2014.08.005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The word 'epimutation' is often used in a manner that can be misinterpreted. The strict definition of epimutation is a heritable change in gene activity that is not associated with a DNA mutation but rather with gain or loss of DNA methylation or other heritable modifications of chromatin. Unfortunately, there is a growing tendency in the cancer field to use the word in situations in which underlying DNA sequence changes have occurred.

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页码：519 / 520

页数：2

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