Antiviral activities of plants occurring in the state of Minas Gerais, Brazil. Part 2. Screening Bignoniaceae species

被引：21

作者：

Brandao, Geraldo Celio ^{[1
]}

Kroon, Erna G. ^{[2
]}

dos Santos, Joao Rodrigues ^{[2
]}

Stehmann, Joao Renato ^{[3
]}

Lombardi, Julio A. ^{[4
]}

de Oliveira, Alaide Braga ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Fac Farm, Dept Prod Farmaceut, Lab Fitoquim, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, Virus Lab, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Bot, Inst Ciencias Biol, Lab Taxon Vegetal, BR-31270901 Belo Horizonte, MG, Brazil

[4] Univ Estadual Paulista, Inst Biociencias Rio Claro, Dept Bot, BR-13506900 Rio Claro, SP, Brazil

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2010年 / 20卷 / 05期

关键词：

Bignoniaceae; antiviral activity; cytotoxicity; HHV-1; VACV; EMCV; HERPES-SIMPLEX VIRUS; ARRABIDAEA-CHICA; NATURAL-PRODUCTS; MANGIFERIN; EXTRACTS; INTERFERON; INFECTION; SYNOPSIS; LEAVES; DRUGS;

D O I：

10.1590/S0102-695X2010005000035

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ethanol extracts of eighteen Bignoniaceae species have been evaluated by the MTT assay for cytotoxicity in Vero cells and for antiviral activity against Human herpes virus type 1, Vaccinia virus and murine Encephalomyocarditis virus. Among such species, seven are reported to be of traditional medicinal use No cytotoxicity was observed for most of the extracts up to the concentration of 500 mu g/mL. Fourteen (50%) of the 28 extracts assayed have disclosed antiviral activity with EC50 values in the range of 4.6+0.3 to 377.2+17.7 mu g/mL. Only two species, Arrabidaea samydoides and Callichlamys latifolia, have shown activity against all the three viruses. The extracts were chemically characterized by their TLC and HPLC-DAD profiles. Mangiferin is the major constituent of A. samydoides but the isolated compound has been less active than the crude extract. This is the first report on the antiviral evaluation of the eighteen Bignoniaceae species assayed.

引用

页码：742 / 750

页数：9

共 35 条

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