Successful Treatment of Posttransplant Recurrent Complement C3 Glomerulopathy with Eculizumab

被引：0

作者：

Sahin, Hatice ^{[1
]}

Oguz, Ebru Gok ^{[1
]}

Akoglu, Hadim ^{[2
]}

Atilgan, Gokhan ^{[1
]}

Okyay, Gulay Ulusal ^{[1
]}

Gursoy, Guner Karaveli ^{[1
]}

Teymur, Tugba Kip ^{[1
]}

Ertoy, Dilek ^{[3
]}

Canbakan, Basol ^{[1
]}

Ayli, Mehmet Deniz ^{[1
]}

机构：

[1] Diskapi Yildirim Beyazit Educ & Res Hosp, Dept Nephrol, Ankara, Turkey

[2] Hlth Sci Univ, Gulhane Training & Res Hosp, Dept Nephrol, Ankara, Turkey

[3] Hacettepe Univ, Dept Pathol, Ankara, Turkey

来源：

IRANIAN JOURNAL OF KIDNEY DISEASES | 2018年 / 12卷 / 05期

关键词：

eculizumab; complement C3 glomerulopathy; kidney transplantation; DENSE-DEPOSIT DISEASE; GLOMERULONEPHRITIS; ABNORMALITIES;

D O I：

暂无

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Two-thirds of complement C3 glomerulopathy (C3G) recur after transplantation and commonly cause graft loss. There is not a standard treatment protocol for these cases. We present a kidney transplant patient with recurrent C3G who was successfully treated with eculizumab. Nephrotic proteinuria and hernaturia occurred and creatinine levels increased after transplantation. A graft biopsy revealed recurrent C3G. The patient was administered 250 mg pulse methylprednisolone for 3 days and had 9 sessions of plasmapheresis. Since elevated creatinine levels and proteinuria persisted, eculizumab was instituted. A complete remission was observed after 9-month maintenance eculizumab treatment. Eculizumab may be a potentially effective option in kidney transplant patients with recurrent C3G unresponsive to other treatment modalities.

引用

页码：315 / 318

页数：4

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