Epilepsy surgery following brain tumor resection in children Clinical article

被引:6
作者
Tian, Ashley G. [1 ]
Edwards, Michael S. B. [1 ]
Williams, Nicole J. [2 ]
Olson, Donald M. [2 ]
机构
[1] Stanford Univ, Dept Neurosurg, Med Ctr, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Neurol, Med Ctr, Stanford, CA 94305 USA
关键词
epilepsy surgery; brain tumor; pediatric neurosurgery; electrocorticography; TEMPORAL-LOBE EPILEPSY; LOW-GRADE TUMORS; SEIZURES; REOPERATION;
D O I
10.3171/2010.12.PEDS10293
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Object. Intractable epilepsy following successful brain tumor surgery in children may have several underlying causes such as residual tumor, cortical dysplasia, and gliosis. The authors reviewed the cases of children who had previously undergone resection of a brain tumor only to have medically refractory seizures postoperatively. Methods. The authors performed a retrospective case review of 9 children who underwent brain tumor surgery 2-13 years before undergoing a second surgery to try and control their seizures. Results. Eight of 9 children had seizures at the time of tumor presentation. Tumor types included ganglioglioma, dysembryoplastic neuroepithelial tumor, pilocytic astrocytoma, oligodendroglioma, ependymoma, and choroid plexus papilloma. All patients achieved a seizure-free interval before intractable seizures recurred. After the second operation, 3 children were seizure free, 1 only had auras, 2 had rare complex partial seizures, and 3 continued to have relatively frequent seizures, although the frequency and severity were reduced. Seven of 9 patients had pathology showing residual tumor. Conclusions. Epilepsy surgery following earlier brain tumor surgery can provide substantial benefit with reduced seizure number and severity. Despite reassuring brain imaging results, residual tumor was present more often than expected in pathological specimens. (DOI: 10.3171/2010.12.PEDS10293)
引用
收藏
页码:229 / 234
页数:6
相关论文
共 17 条
[1]   2ND OPERATION AFTER THE FAILURE OF PREVIOUS RESECTION FOR EPILEPSY [J].
AWAD, IA ;
NAYEL, MH ;
LUDERS, H .
NEUROSURGERY, 1991, 28 (04) :510-518
[2]   EPILEPSY AND BRAIN-TUMORS - IMPLICATIONS FOR TREATMENT [J].
CASCINO, GD .
EPILEPSIA, 1990, 31 :S37-S44
[3]   REOPERATION FOR RECURRENT TEMPORAL-LOBE EPILEPSY [J].
GERMANO, IM ;
POULIN, N ;
OLIVIER, A .
JOURNAL OF NEUROSURGERY, 1994, 81 (01) :31-36
[4]   Seizure outcome of epilepsy surgery in focal epilepsies associated with temporomesial glioneuronal tumors: lesionectomy compared with tailored resection Clinical article [J].
Giulioni, Marco ;
Rubboli, Guido ;
Marucci, Gianluca ;
Martinoni, Matteo ;
Volpi, Lilia ;
Michelucci, Roberto ;
Marliani, Anna Federica ;
Bisulli, Francesca ;
Tinuper, Paolo ;
Castana, Laura ;
Sartori, Ivana ;
Calbucci, Fabio .
JOURNAL OF NEUROSURGERY, 2009, 111 (06) :1275-1282
[5]   Failed surgery for epilepsy - A study of persistence and recurrence of seizures following temporal resection [J].
Hennessy, MJ ;
Elwes, RDC ;
Binnie, CD ;
Polkey, CE .
BRAIN, 2000, 123 :2445-2466
[6]   Predicting outcome following reoperation for medically intractable epilepsy [J].
Holmes, MD ;
Wilensky, AJ ;
Ojemann, LM ;
Ojemann, GA .
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 1999, 8 (02) :103-106
[7]   Seizures as the presenting symptom of brain tumours in children [J].
Ibrahim, K ;
Appleton, R .
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2004, 13 (02) :108-112
[8]   Seizures in children with low-grade tumors: outcome after tumor resection and risk factors for uncontrolled seizures [J].
Khan, RB ;
Boop, FA ;
Onar, A ;
Sanford, RA .
JOURNAL OF NEUROSURGERY, 2006, 104 (06) :377-382
[9]   Epilepsy surgery in children: outcomes and complications [J].
Kim, Seung-Ki ;
Wang, Kyu-Chang ;
Hwang, Yong-Seung ;
Kim, Ki Joong ;
Chae, Jong Hee ;
Kim, In-One ;
Cho, Byung-Kyu .
JOURNAL OF NEUROSURGERY-PEDIATRICS, 2008, 1 (04) :277-283
[10]   CONTROL OF TEMPORAL-LOBE EPILEPSY FOLLOWING EN-BLOC RESECTION OF LOW-GRADE TUMORS [J].
KIRKPATRICK, PJ ;
HONAVAR, M ;
JANOTA, I ;
POLKEY, CE .
JOURNAL OF NEUROSURGERY, 1993, 78 (01) :19-25