New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus

被引：19

作者：

Qu, Di ^{[1
]}

Li, Jing ^{[2
]}

Yang, Xiao-Hui ^{[2
]}

Zhang, Zi-Dan ^{[3
]}

Luo, Xiao-Xing ^{[1
]}

Li, Ming-Kai ^{[1
]}

Li, Xia ^{[4
]}

机构：

[1] Fourth Mil Med Univ, Sch Pharm, Dept Pharmacol, Xian 710032, Peoples R China

[2] Xian Univ, Sch Chem & Chem Engn, Xian 710065, Peoples R China

[3] Tianjin Univ, Sch Sci, Dept Phys, Tianjin 300072, Peoples R China

[4] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China

来源：

MOLECULES | 2014年 / 19卷 / 12期

关键词：

biscoumarin; Staphylococcus aureus; minimum inhibitory concentration; 4-HYDROXYCOUMARIN; RESISTANCE;

D O I：

10.3390/molecules191219868

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five novel biscoumarins 1-5 were synthesized and characterized. In these compounds, two classical asymmetrical intramolecular O-H center dot center dot center dot O hydrogen bonds were used to stabilize the whole structures and the HB energies were performed with the density functional theory (DFT) [B3LYP/6-31G*] method. The five compounds were evaluated for their in vitro antibacterial activities against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC) by the means of minimum inhibitory concentration and time-kill curves.

引用

页码：19868 / 19879

页数：12

共 25 条

[1] Cytotoxicity, antioxidant, and antimicrobial activities of novel 2-quinolone derivatives derived from coumarin [J].

Al-Amiery, Ahmed A. ;

Al-Bayati, Redha I. H. ;

Saour, Kawkab Y. ;

Radi, Mahdi F. .

RESEARCH ON CHEMICAL INTERMEDIATES, 2012, 38 (02) :559-569

[2]

[Anonymous], 1997, SHELXL 97 PROGRAM CR

[3] METHICILLIN-RESISTANT STAPHYLOCOCCI [J].

BARBER, M .

JOURNAL OF CLINICAL PATHOLOGY, 1961, 14 (04) :385-&

[4] New antibiotics for bad bugs: where are we? [J].

Bassetti, Matteo ;

Merelli, Maria ;

Temperoni, Chiara ;

Astilean, Augusta .

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS, 2013, 12

[5] DENSITY-FUNCTIONAL THERMOCHEMISTRY .3. THE ROLE OF EXACT EXCHANGE [J].

BECKE, AD .

JOURNAL OF CHEMICAL PHYSICS, 1993, 98 (07) :5648-5652

[6]

Clinical and Laboratory Standards Institute, 2009, M100S19 CLSI

[7]

Cravotto G, 2003, SYNTHESIS-STUTTGART, P1286

[8]

Frisch M. J., 2016, Gaussian 03 Revision B.03

[9] Pathogenesis of methicillin-resistant Staphylococcus aureus infection [J].

Gordon, Rachel J. ;

Lowy, Franklin D. .

CLINICAL INFECTIOUS DISEASES, 2008, 46 :S350-S359

[10] Clinical relevance of mupirocin resistance in Staphylococcus aureus [J].

Hetem, D. J. ;

Bonten, M. J. M. .

JOURNAL OF HOSPITAL INFECTION, 2013, 85 (04) :249-256

← 1 2 3 →