The diagnostic, prognostic and therapeutic potential of circulating microRNAs in ovarian cancer

被引：16

作者：

Aboutalebi, Hamideh ^{[1
]}

Bahrami, Afsane ^{[2
]}

Soleimani, Atena ^{[3
,4
]}

Saeedi, Nikoo ^{[5
]}

Rahmani, Farzad ^{[11
]}

Khazaei, Majid ^{[6
]}

Fiuji, Hamid ^{[7
]}

Shafiee, Mojtaba ^{[8
]}

Ferns, Gordon A. ^{[9
]}

Avan, Amir ^{[10
]}

Hassanian, Seyed Mahdi ^{[3
,9
]}

机构：

[1] Mashhad Univ Med Sci, Fac Med, Dept Anat, Mashhad, Razavi Khorasan, Iran

[2] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran

[3] Mashhad Univ Med Sci, Fac Med, Dept Clin Biochem, Mashhad, Razavi Khorasan, Iran

[4] Mashhad Univ Med Sci, Fac Med, Student Res Comm, Mashhad, Razavi Khorasan, Iran

[5] Islamic Azad Univ, Mashhad Branch, Student Res Comm, Mashhad, Razavi Khorasan, Iran

[6] Mashhad Univ Med Sci, Fac Med, Dept Med Physiol, Mashhad, Razavi Khorasan, Iran

[7] Payame Noor Univ, Dept Biochem, Mashhad, Razavi Khorasan, Iran

[8] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK, Canada

[9] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England

[10] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran

[11] Iranshahr Univ Med Sci, Iranshahr, Iran

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2020年 / 124卷

关键词：

Ovarian cancer; Extracellular microRNA; Circulating microRNA; Biomarker; NF-KAPPA-B; CISPLATIN RESISTANCE; MESSENGER-RNAS; LUNG-CANCER; WHOLE-BLOOD; EXPRESSION; CELLS; BIOMARKERS; SERUM; SENSITIVITY;

D O I：

10.1016/j.biocel.2020.105765

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ovarian cancer (OC) is often diagnosed at an advanced stage because of the late onset of symptoms, and this together with the lack of effective treatments, has meant it is associated with a very high mortality. The aberrant expression of MicroRNA (miRNA) contributes to the initiation and development of human tumors including OC. Several miRNAs are secreted by tumor cells and can be identified in body fluids. Serum miRNAs levels are associated with several clinical conditions, and may be used to predict prognosis and response to treatments in some cancers including OC. This review summarizes the current progresses regarding the potential applications of circulating miRNA as innovative biomarkers in OC.

引用

页数：8

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