Synaptic Connections of the Neurokinin 1 Receptor-Like Immunoreactive Neurons in the Rat Medullary Dorsal Horn

被引：4

作者：

Qi, Jian ^{[1
,2
]}

Zhang, Hua ^{[1
,2
]}

Guo, Jun ^{[3
]}

Yang, Le

Wang, Wen ^{[1
,2
]}

Chen, Tao ^{[1
,2
]}

Li, Hui ^{[1
,2
]}

Wu, Sheng-Xi ^{[1
,2
]}

Li, Yun-Qing ^{[1
,2
]}

机构：

[1] Fourth Mil Med Univ, Dept Anat, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, KK Leung Brain Res Ctr, Xian 710032, Peoples R China

[3] Fourth Mil Med Univ, Dept Physiol, Xian 710032, Peoples R China

来源：

PLOS ONE | 2011年 / 6卷 / 08期

基金：

中国国家自然科学基金;

关键词：

SUBSTANCE-P RECEPTOR; ROSTRAL VENTROMEDIAL MEDULLA; SEROTONIN-CONTAINING AXONS; SPINAL TRIGEMINAL NUCLEUS; I PROJECTION NEURONS; LAMINA-I; INHIBITORY NEUROTRANSMISSION; SUPERFICIAL LAMINAE; NOXIOUS-STIMULATION; GELATINOSA NEURONS;

D O I：

10.1371/journal.pone.0023275

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The synaptic connections between neurokinin 1 (NK1) receptor-like immunoreactive (LI) neurons and gamma-aminobutyric acid (GABA)-, glycine (Gly)-, serotonin (5-HT)-or dopamine-beta-hydroxylase (DBH, a specific marker for norepinephrinergic neuronal structures)-LI axon terminals in the rat medullary dorsal horn (MDH) were examined under electron microscope by using a pre-embedding immunohistochemical double-staining technique. NK1 receptor-LI neurons were observed principally in laminae I and III, only a few of them were found in lamina II of the MDH. GABA-, Gly-, 5-HT-, or DBH-LI axon terminals were densely encountered in laminae I and II, and sparsely in lamina III of the MDH. Some of these GABA-, Gly-, 5-HT-, or DBH-LI axon terminals were observed to make principally symmetric synapses with NK1 receptor-LI neuronal cell bodies and dendritic processes in laminae I, II and III of the MDH. The present results suggest that neurons expressing NK1 receptor within the MDH might be modulated by GABAergic and glycinergic inhibitory intrinsic neurons located in the MDH and 5-HT- or norepinephrine (NE)-containing descending fibers originated from structures in the brainstem.

引用

页数：8

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