MECHANISMS OF DISEASE Development of Antiretroviral Drug Resistance

被引：168

作者：

Wainberg, Mark A. ^{[1
]}

Zaharatos, Gerasimos J. ^{[1
]}

Brenner, Bluma G. ^{[1
]}

机构：

[1] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, AIDS Ctr, Montreal, PQ H3T 1E2, Canada

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2011年 / 365卷 / 07期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; HIV-1; SUBTYPE-C; TO-CHILD TRANSMISSION; SINGLE-DOSE NEVIRAPINE; REVERSE-TRANSCRIPTASE INHIBITORS; NON-B SUBTYPES; VIROLOGICAL FAILURE; IN-VITRO; K65R RESISTANCE; SOUTHERN BRAZIL;

D O I：

10.1056/NEJMra1004180

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An urgent global priority is the optimization of treatment strategies for HIV infection, regardless of geographic locale. It is reassuring that current antiretroviral strategies appear to be effective against a broad spectrum of HIV subtypes. Suboptimal therapies that include such drugs as stavudine and didanosine can facilitate the selection of the K65R mutation, which, in turn, may limit many secondary treatment options. In addition, suboptimal regimens put patients at risk for the development of NNRTI-resistance mutations. An understanding of drug-resistance patterns among non-B subtype infections may help to optimize the selection of first-line regimens and limit the acquisition of resistance. Copyright © 2011 Massachusetts Medical Society. All rights reserved.

引用

页码：637 / 646

页数：10

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