Co-presence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian colorectal cancer samples

被引：26

作者：

Malki, Mohammed I. ^{[1
]}

Gupta, Ishita ^{[1
,2
]}

Fernandes, Queenie ^{[1
,2
]}

Aboulkassim, Tahar ^{[3
]}

Yasmeen, Amber ^{[3
]}

Vranic, Semir ^{[1
]}

Al Moustafa, Ala-Eddin ^{[1
,2
]}

Al-Thawadi, Hamda A. ^{[1
]}

机构：

[1] Qatar Univ, QU Hlth, Coll Med, Doha, Qatar

[2] Qatar Univ, Biomed Res Ctr, Doha, Qatar

[3] Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Segal Canc Ctr, Montreal, PQ, Canada

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2020年 / 16卷 / 10期

关键词：

EBV; high-risk HPV; colorectal cancer; Syrian population; cancer phenotype; ASSOCIATION; POPULATION; INFECTIONS; FASCIN; WOMEN;

D O I：

10.1080/21645515.2020.1726680

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We recently performed two studies exploring the presence of Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 in human colorectal cancers from the Syrian population. Herein, we report that EBV and high-risk HPVs are co-present in colorectal cancers from Syria. We reveal that 17 (similar to 17%) of 102 cancer samples are positive for both EBV and high-risk HPVs and their co-presence is associated with high/intermediate grade invasive carcinomas. These data suggest that EBV and high-risk HPVs are co-present in human colorectal cancers where they might cooperate on the initiation and/or progression of these cancers. Thus, we believe that future studies are necessary to confirm the co-presence of these oncoviruses and their cooperative role in human colorectal carcinogenesis.

引用

页码：2403 / 2407

页数：5

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