Combination Radiation Therapy and Imipridone ONC201 for the Treatment of Solid Tumors

被引：1
|
作者：
Jhawar, S. R. [1 ]
Goyal, S. [2 ]
Thandoni, A. [1 ]
Wu, H. [1 ]
Hassan, S. [3 ]
Schiff, D. S. [1 ]
Allen, J. [4 ]
Stogniew, M. [4 ]
Tarapore, R. [4 ]
Stein, M. [1 ]
Bertino, J. [1 ]
Haffty, B. G., Jr. [1 ]
Zloza, A. [1 ,5 ]
机构：
[1] Rutgers Canc Inst New Jersey, New Brunswick, NJ USA
[2] Rutgers Canc Inst New Jersey, Dept Radiat Oncol, New Brunswick, NJ USA
[3] Rutgers State Univ, New Brunswick, NJ USA
[4] Oncoceutics Inc, Philadelphia, PA USA
[5] Rutgers Robert Wood Johnson Med Sch, Dept Surg, New Brunswick, NJ USA
来源：
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2017年 / 99卷 / 02期
关键词：
D O I：
10.1016/j.ijrobp.2017.06.2041
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3424
引用
收藏
页码：E598 / E598
页数：1
相关论文
共 50 条
  • [21] First-in-human trial of ONC201 in patients with refractory solid tumors.
    Stein, Mark N.
    Chan, Nancy
    Silk, Ann W.
    Fang, Bruno
    Kaufman, Howard
    Haffty, Bruce George
    Saunders, Tracie
    Najmi, Saltanat
    Zheng, Ling
    Stogniew, Martin
    Allen, Joshua E.
    Oster, Wolfgang
    Bertino, Joseph R.
    Mehnert, Janice M.
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [22] THE SMALL MOLECULE IMIPRIDONE ONC201 IS ACTIVE IN GLIOBLASTOMA WITH DRD2 PATHWAY DYSREGULATION
    Prabhu, Varun Vijay
    Madhukar, Neel
    Kline, C. Leah B.
    Tarapore, Rohinton S.
    El-Deiry, Wafik
    Elemento, Olivier
    Rucker, Joseph
    Doranz, Benjamin
    Doherty, Faye
    VanEngelenburg, Alexander
    Durrant, Jessica
    Benes, Cyril
    Arrillaga-Romany, Isabel
    Oster, Wolfgang
    Allen, Joshua E.
    NEURO-ONCOLOGY, 2017, 19 : 60 - 60
  • [23] ROLE OF CLPP AND MITOCHONDRIAL METABOLISM IN THE ANTI-CANCER EFFECTS OF IMIPRIDONE ONC201 AND ONC206 IN GLIOBLASTOMA AND DIPG
    Foster, Scott
    Lee, Andrew
    Maranto, Cristina
    Allen, Joshua E.
    Lanier, Randall
    Sethna, Phiroze
    Prabhu, Varun V.
    NEURO-ONCOLOGY, 2022, 24 : 234 - 234
  • [24] Antitumorigenic effect of combination treatment with ONC201 and TRAIL in endometrial cancer in vitro and in vivo
    Ray, Jocelyn E.
    Ralff, Marie D.
    Jhaveri, Aakash
    Zhou, Lanlan
    Dicker, David T.
    Ross, Eric A.
    El-Deiry, Wafik S.
    CANCER BIOLOGY & THERAPY, 2021, 22 (10-12) : 554 - 563
  • [25] The small molecule imipridone ONC201 is active in tumor types with dysregulation of the DRD2 pathway
    Madhukar, Neel
    Prabhu, Varun Vijay
    Dardenne, Etienne
    Doherty, Faye
    VanEngelenburg, Alexander
    Tarapore, Rohinton
    Garnett, Mathew
    McDermott, Ultan
    Benes, Cyril
    Oster, Wolfgang
    El-Deiry, Wafik
    Stein, Mark
    Rickman, David
    Allen, Joshua
    Elemento, Olivier
    CANCER RESEARCH, 2017, 77
  • [26] First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors
    Stein, Mark N.
    Bertino, Joseph R.
    Kaufman, Howard L.
    Mayer, Tina
    Moss, Rebecca
    Silk, Ann
    Chan, Nancy
    Malhotra, Jyoti
    Rodriguez, Lorna
    Aisner, Joseph
    Aiken, Robert D.
    Haffty, Bruce G.
    DiPaola, Robert S.
    Saunders, Tracie
    Zloza, Andrew
    Damare, Sherri
    Beckett, Yasmeen
    Yu, Bangning
    Najmi, Saltanat
    Gabel, Christian
    Dickerson, Siobhan
    Zheng, Ling
    El-Deiry, Wafik S.
    Allen, Joshua E.
    Stogniew, Martin
    Oster, Wolfgang
    Mehnert, Janice M.
    CLINICAL CANCER RESEARCH, 2017, 23 (15) : 4163 - 4169
  • [27] THE IMIPRIDONE ONC201 IN COMBINATION WITH THE ONCOLYTIC ADENOVIRUS DELTA-24-RGD HAS A SYNERGISTIC EFFECT IN PRECLINICAL MODELS OF PHGGS AND DMGS
    de la Nava, Daniel
    Ausejo-Mauleon, Iker
    Laspidea, Virginia
    Marrodan, Lucia
    Zalacain, Marta
    Herrador-Canete, Guillermo
    Nazarian, Javad
    Mueller, Sabine
    Allen, Joshua E.
    Fueyo, Juan
    Gomez-Manzano, Candelaria
    Gupta, Sumit
    Patino, Ana
    Alonso, Marta M.
    NEURO-ONCOLOGY, 2021, 23 : 20 - 20
  • [28] ONC201 IN COMBINATION WITH RADIATION EXHIBITS SYNERGISTIC EFFICACY IN HIGH GRADE GLIOMAS AND OTHER ADVANCED CANCERS
    Tarapore, Rohinton
    Jhawar, Sachin
    Stein, Mark
    Haffty, Bruce
    Zloza, Andrew
    Mueller, Sabine
    Zhang, Jie
    Amoroso, Francesca
    Mills, Ian
    Oster, Wolfgang
    Allen, Joshua
    NEURO-ONCOLOGY, 2018, 20 : 72 - 72
  • [29] Differentiated receptor pharmacology of imipridone ONC201: The first DRD2 antagonist in clinical development for oncology
    Madhukar, Neel
    Prabhu, Varun Vijay
    Anantharaman, Lakshmi
    Sulli, Chidananda
    Davidson, Edgar
    Deacon, Sean
    Tarapore, Rohinton
    Rucker, Joseph
    Charter, Neil
    Doranz, Banjamin
    Oster, Wolfgang
    Elemento, Olivier
    Allen, Joshua
    CANCER RESEARCH, 2017, 77
  • [30] Immunomodulatory activity of selective DRD2 antagonist ONC201, an imipridone, in metastatic endometrial cancer (mEC)
    Tarapore, Rohinton S.
    Prabhu, Varun V.
    Mok, Samuel C.
    Yeung, Chilam Au
    Rodriguez, Lorna
    Girda, Eugenia
    Mantia-Smaldone, Gina
    Bae-Jump, Victoria
    Lu, Guangrong
    Oster, Wolfgang
    Allen, Joshua E.
    CANCER RESEARCH, 2020, 80 (16)
12345