Coexistence of KRAS mutation with mutant but not wild-type EGFR predicts response to tyrosine-kinase inhibitors in human lung cancer

被引：30

作者：

Choughule, A. ^{[1
]}

Sharma, R. ^{[1
,2
]}

Trivedi, V. ^{[1
,2
]}

Thavamani, A. ^{[1
,2
]}

Noronha, V. ^{[1
]}

Joshi, A. ^{[1
]}

Desai, S. ^{[3
]}

Chandrani, P. ^{[2
]}

Sundaram, P. ^{[2
]}

Utture, S. ^{[1
]}

Jambhekar, N. ^{[3
]}

Gupta, S. ^{[1
]}

Aich, J. ^{[2
]}

Prabhash, K. ^{[1
]}

Dutt, A. ^{[2
]}

机构：

[1] Tata Mem Hosp, Tata Mem Ctr, Dept Med Oncol, Bombay 400012, Maharashtra, India

[2] Tata Mem Hosp, Adv Ctr Treatment Res & Educ Canc, Navi Mumbai, India

[3] Tata Mem Hosp, Tata Mem Ctr, Dept Pathol, Bombay 400012, Maharashtra, India

来源：

BRITISH JOURNAL OF CANCER | 2014年 / 111卷 / 11期

基金：

英国惠康基金;

关键词：

GROWTH-FACTOR-RECEPTOR; GEFITINIB; THERAPY; GENE; ERLOTINIB; SURVIVAL; FEATURES;

D O I：

10.1038/bjc.2014.401

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：2203 / 2204

页数：4

共 19 条

[1]

[Anonymous], P AM SOC CLIN S623S

[2]

Benesova L, 2010, ANTICANCER RES, V30, P1667

[3] Frequency of EGFR Mutations in 907 Lung Adenocarcioma Patients of Indian Ethnicity [J].

Chougule, Anuradha ;

Prabhash, Kumar ;

Noronha, Vanita ;

Joshi, Amit ;

Thavamani, Abhishek ;

Chandrani, Pratik ;

Upadhyay, Pawan ;

Utture, Sagarika ;

Desai, Saral ;

Jambhekar, Nirmala ;

Dutt, Amit .

PLOS ONE, 2013, 8 (10)

[4] Biomarker Analyses and Final Overall Survival Results From a Phase III, Randomized, Open-Label, First-Line Study of Gefitinib Versus Carboplatin/Paclitaxel in Clinically Selected Patients With Advanced Non-Small-Cell Lung Cancer in Asia (IPASS) [J].

Fukuoka, Masahiro ;

Wu, Yi-Long ;

Thongprasert, Sumitra ;

Sunpaweravong, Patrapim ;

Leong, Swan-Swan ;

Sriuranpong, Virote ;

Chao, Tsu-Yi ;

Nakagawa, Kazuhiko ;

Chu, Da-Tong ;

Saijo, Nagahiro ;

Duffield, Emma L. ;

Rukazenkov, Yuri ;

Speake, Georgina ;

Jiang, Haiyi ;

Armour, Alison A. ;

To, Ka-Fai ;

Yang, James Chih-Hsin ;

Mok, Tony S. K. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (21) :2866-2874

[5] Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome [J].

Ihle, Nathan T. ;

Byers, Lauren A. ;

Kim, Edward S. ;

Saintigny, Pierre ;

Lee, J. Jack ;

Blumenschein, George R. ;

Tsao, Anne ;

Liu, Suyu ;

Larsen, Jill E. ;

Wang, Jing ;

Diao, Lixia ;

Coombes, Kevin R. ;

Chen, Lu ;

Zhang, Shuxing ;

Abdelmelek, Mena F. ;

Tang, Ximing ;

Papadimitrakopoulou, Vassiliki ;

Minna, John D. ;

Lippman, Scott M. ;

Hong, Waun K. ;

Herbst, Roy S. ;

Wistuba, Ignacio I. ;

Heymach, John V. ;

Powis, Garth .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2012, 104 (03) :228-239

[6] Mutations of the epidermal growth factor receptor gene in lung cancer:: Biological and clinical implications [J].

Kosaka, T ;

Yatabe, Y ;

Endoh, H ;

Kuwano, H ;

Takahashi, T ;

Mitsudomi, T .

CANCER RESEARCH, 2004, 64 (24) :8919-8923

[7] Coexistence of EGFR with KRAS, or BRAF, or PIK3CA somatic mutations in lung cancer: a comprehensive mutation profiling from 5125 Chinese cohorts [J].

Li, S. ;

Li, L. ;

Zhu, Y. ;

Huang, C. ;

Qin, Y. ;

Liu, H. ;

Ren-Heidenreich, L. ;

Shi, B. ;

Ren, H. ;

Chu, X. ;

Kang, J. ;

Wang, W. ;

Xu, J. ;

Tang, K. ;

Yang, H. ;

Zheng, Y. ;

He, J. ;

Yu, G. ;

Liang, N. .

BRITISH JOURNAL OF CANCER, 2014, 110 (11) :2812-2820

[8] KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer [J].

Lièvre, A ;

Bachet, JB ;

Le Corre, D ;

Boige, V ;

Landi, B ;

Emile, JF ;

Côté, JF ;

Tomasic, G ;

Penna, C ;

Ducreux, M ;

Rougier, P ;

Penault-Llorca, F ;

Laurent-Puig, P .

CANCER RESEARCH, 2006, 66 (08) :3992-3995

[9] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [J].

Lynch, TJ ;

Bell, DW ;

Sordella, R ;

Gurubhagavatula, S ;

Okimoto, RA ;

Brannigan, BW ;

Harris, PL ;

Haserlat, SM ;

Supko, JG ;

Haluska, FG ;

Louis, DN ;

Christiani, DC ;

Settleman, J ;

Haber, DA .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2129-2139

[10] KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: A meta-analysis of 22 studies [J].

Mao, Chen ;

Qiu, Li-Xin ;

Liao, Ru-Yan ;

Du, Fang-Bing ;

Ding, Hong ;

Yang, Wan-Chun ;

Li, Jin ;

Chen, Qing .

LUNG CANCER, 2010, 69 (03) :272-278

← 1 2 →