Tipping the apoptotic balance in Alzheimer's disease - The abortosis concept

被引：19

作者：

Raina, AK

Zhu, XW

Shimohama, S

Perry, G

Smith, MA ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[2] Kyoto Univ, Grad Sch Med, Dept Neurol, Kyoto 606, Japan

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2003年 / 39卷 / 03期

关键词：

Alzheimer's disease; apoptosis; caspases; cell death; neurodegeneration;

D O I：

10.1385/CBB:39:3:249

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanisms underlying the selective neuronal death in Alzheimer's disease are largely unresolved. Nonetheless, it is apparent that the environment of the diseased brain is extremely rich in proapoptotic stimuli and that these lead to an activation of the apoptotic death cascade. However, there is surprisingly little evidence for the completion of the death pathway indicating that the apoptotic death program is terminated by a mechanism termed abortosis. This review discusses the concept of abortosis in relation to Alzheimer's disease.

引用

页码：249 / 255

页数：7

共 44 条

[1] Multiple caspases are involved in β-amyloid-induced neuronal apoptosis [J].