The Role of Cancer-associated Fibroblasts in Tumorigenesis of Gastric Cancer

被引：28
作者：
Ma, Zhilong [1 ]
Chen, Min [2 ]
Yang, Xiaohu [3 ]
Xu, Bin [1 ]
Song, Zhenshun [1 ]
Zhou, Bo [1 ]
Yang, Tingsong [1 ]
机构：
[1] Tongji Univ, Dept Gen Surg, Shanghai Peoples Hosp 10, 301 Yanchang Middle Rd, Shanghai 200072, Peoples R China
[2] Dahua Hosp, Dept Pathol, 901 Old Humin Rd, Shanghai, Peoples R China
[3] Tongji Univ, Dept Anesthesiol, Shanghai East Hosp, 150 JiMo Rd, Shanghai, Peoples R China
来源：
CURRENT PHARMACEUTICAL DESIGN | 2018年 / 24卷 / 28期
基金：
上海市自然科学基金;
关键词：
Cancer-associated fibroblasts; tumor microenvironment; gastric cancer; tumorigenesis; angiogenesis; extracellular matrix; CARCINOMA-ASSOCIATED FIBROBLASTS; STROMAL FIBROBLASTS; DOWN-REGULATION; ACTIVATION PROTEIN; TUMOR PROGRESSION; CELL INVASION; EXPRESSION; PROMOTES; METASTASIS; GALECTIN-1;
D O I：
10.2174/1381612824666180601094056
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cancer-associated fibroblasts (CAFs) are an important cell type present in solid tumor microenvironments, including that of gastric cancer. They play a vital role in the promotion of tumorigenesis, angiogenesis, and cancer progression through paracrine signaling and modulation of the extracellular matrix. However, the exact molecular mechanism underlying the interaction between gastric cancer cells and stromal fibroblasts remains poorly understood. Recent studies have demonstrated that various factors, such as gene and microRNA variations, are involved in this process. This review discusses recent advances in understanding how these factors are regulated in CAFs and how they affect tumor biology, which may improve our understanding of their role in gastric cancer tumorigenesis and progression and provide new promising targets for therapeutic strategies.
引用
收藏
页码：3297 / 3302
页数：6
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