Synthesis and study of antibacterial and antifungal activities of novel 8-methyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones

被引：41

作者：

Balasubramanian, S ^{[1
]}

Ramalingan, C ^{[1
]}

Aridoss, G ^{[1
]}

Kabilan, S ^{[1
]}

机构：

[1] Annamalai Univ, Dept Chem, Annamalainagar 608002, Tamil Nadu, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 40卷 / 07期

关键词：

piperidin-4-one; 1,2,4-triazolidin-3-thiones; hydrogen peroxide; antibacterial activity; antifungal activity;

D O I：

10.1016/j.ejmech.2005.02.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some novel spiropiperidinyl-1,2,4-triazolidin-3-thiones have been synthesized and studied for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Candida-6, Candida-51, Aspergillus niger and Aspergillus flavus. Compounds 30-32 exhibited potent in vitro antibacterial activity against E. coli and P. aeruginosa whereas the same set of compounds exerted potent in vitro antifungal activity against Candida-6, A. niger and A. flavus. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：694 / 700

页数：7

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