One-pot synthesis of N-allylthioureas using supported reagents

被引：18

作者：

Aoyama, T ^{[1
]}

Murata, S

Nagata, Y

Takido, T

Kodomari, M

机构：

[1] Nihon Univ, Coll Sci & Technol, Dept Mat & Appl Chem, Chiyoda Ku, Tokyo 1018308, Japan

[2] Shibaura Inst Technol, Dept Appl Chem, Minato Ku, Tokyo 1088548, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 29期

关键词：

thiourea; supported reagents; one-pot synthesis;

D O I：

10.1016/j.tetlet.2005.05.063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method has been developed for the synthesis of N-allylthioureas from allylic bromides in one-pot by using a supported reagents system, KSCN/SiO2-RNH3OAc/Al2O3, in which allyl bromide reacts first with KSCN/SiO2 and the product, allyl isothiocyanate, reacts with RNH3OAc/Al2O3 to give the final product, N-allylthiourea, in good yield. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4875 / 4878

页数：4

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