TopMSV: A Web-Based Tool for Top-Down Mass Spectrometry Data Visualization

被引：4

作者：

Choi, In Kwon ^{[1
]}

Jiang, Tianze ^{[1
]}

Kankara, Sreekanth Reddy ^{[1
]}

Wu, Si ^{[2
]}

Liu, Xiaowen ^{[1
,3
]}

机构：

[1] Purdue Univ, Indiana Univ, Dept BioHlth Informat, Indianapolis, IN 46202 USA

[2] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA

[3] Indiana Univ, Sch Med, Indianapolis, IN 46202 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2021年 / 32卷 / 06期

基金：

美国国家卫生研究院;

关键词：

top-down mass spectrometry; data visualization; software tools; OPEN-SOURCE SOFTWARE; PROTEIN IDENTIFICATION; PROTEOMICS; PROTEOFORMS; PEPTIDE; PACKAGE;

D O I：

10.1021/jasms.0c00460

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Top-down mass spectrometry (MS) investigates intact proteoforms for proteoform identification, characterization, and quantification. Data visualization plays an essential role in top-down MS data analysis because proteoform identification and characterization often involve manual data inspection to determine the molecular masses of highly charged ions and validate unexpected alterations in identified proteoforms. While many software tools have been developed for MS data visualization, there is still a lack of web-based visualization software designed for topdown MS. Here, we present TopMSV, a web-based tool for topdown MS data processing and visualization. TopMSV provides interactive views of top-down MS data using a web browser. It integrates software tools for spectral deconvolution and proteoform identification and uses analysis results of the tools to annotate top-down MS data.

引用

页码：1312 / 1318

页数：7

共 25 条

[1] Top-down proteomics reveals a unique protein S-thiolation switch in Salmonella Typhimurium in response to infection-like conditions [J].