Localization of the neurokinin 1 (NK-1) receptor in the human antrum and duodenum

被引：14
作者：
Smith, VC
Sagot, MA
Couraud, JY
Buchan, AMJ
机构：
[1] Univ British Columbia, Dept Physiol, Vancouver, BC V6T 1Z3, Canada
[2] CEA, Serv Pharmacol & Immunol, DSV DRM, CENS, F-91191 Gif Sur Yvette, France
来源：
NEUROSCIENCE LETTERS | 1998年 / 253卷 / 01期
关键词：
tachykinin receptor; substance p; human intestine; immunocytochemistry;
D O I：
10.1016/S0304-3940(98)00618-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A newly available antibody to the neurokinin-1 receptor (NK-1r) has made it possible to determine the distribution of the NK-1r receptor in human tissue. In the present study the distribution of the NK-1r and substance P have been determined in the human antrum and duodenum by immunocytochemistry. The NK-1r was present on myenteric and submucosal neurons and nerve fibers of the gastro-enteric nervous system. In addition, the receptor was present on spindle-shaped cells in the circular muscle layer, endothelial cells and a population of mucosal cells. In the submucosal plexus NK-1r immunoreactive neurons were surrounded by substance P containing fibers. These results indicate an extensive cellular expression of the NK-1r in the human antrum and duodenum. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：49 / 52
页数：4
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