Circulating exosome levels in the diagnosis of steroid-induced osteonecrosis of the femoral head

被引：37
|
作者：
Zhu, H-Y. [1 ,2 ]
Gao, Y-C. [1 ,2 ]
Wang, Y. [1 ,2 ]
Zhang, C-Q. [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthopaed Surg, 600 Yishan Rd, Shanghai, Peoples R China
来源：
BONE & JOINT RESEARCH | 2016年 / 5卷 / 06期
关键词：
Exosome; Osteonecrosis; Steroid;
D O I：
10.1302/2046-3758.56.BJR-2015-0014.R1
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Objectives Circulating exosomes represent novel biomarkers for multiple diseases. In this study, we investigated whether circulating exosome levels could be used as a diagnostic biomarker for steroid-induced osteonecrosis of the femoral head (ONFH). Methods We assessed the serum exosome level of 85 patients with steroid-induced ONFH and 115 healthy donors by Nanosight detection. We then assessed the diagnostic accuracy of serum exosomes by receiver operating characteristic curve analysis. Results The circulating exosome level of the ONFH group was significantly lower than that of control group. The area under the curve was 0.72, suggesting that the level of serum exosomes has moderate diagnostic accuracy for steroid-induced ONFH. Conclusion Circulating exosome levels are valuable in the diagnosis of steroid-induced ONFH.
引用
收藏
页码：276 / 279
页数：4
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