Cell-matrix interactions, alteration with aging and age associated diseases. A review

被引：18
作者：
Labat-Robert, J [1 ]
机构：
[1] Univ Paris 06, Hop Hotel Dieu, Lab Rech Ophalmol, F-75181 Paris 04, France
来源：
PATHOLOGIE BIOLOGIE | 2001年 / 49卷 / 04期
关键词：
alphallbbeta3; integrin; alphavbeta3; angiogenesis; antagonists; ectopic expression; integrin expression;
D O I：
10.1016/S0369-8114(01)00150-X
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Cell-matrix interactions are mediated by matrix components and cell surface receptors, among them integrins. During aging there are qualitative and quantitative alterations of matrix components. Similar modifications were observed with integrins. During diseases, some integrins appear to be differentially or ectopically expressed. Two examples are given showing the appearance of key receptors and the role of antagonists in their expression opening the field of therapeutic possibilities. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：349 / 352
页数：4
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