Influence of interleukin-1β and interleukin-6 gene polymorphisms on the development of acute pancreatitis

被引：21
作者：
Chi, D. Z. [1 ]
Chen, J. [1 ]
Huang, D. P. [1 ]
机构：
[1] Southern Med Univ, Zhujiang Hosp, Dept Emergency, Guangzhou, Guangdong, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 01期
关键词：
Acute pancreatitis; Chinese; Interleukin-1; beta; Interleukin-6; TUMOR-NECROSIS-FACTOR; SERUM PROFILES; ALCOHOLIC PANCREATITIS; SEVERITY; ASSOCIATION;
D O I：
10.4238/2015.February.3.5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the association between 3 main proinflammatory cytokines [interleukin (IL)-1 beta and IL-6] and the risk of acute pancreatitis. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype IL-1 beta + 3954 C/T (rs1143634) and IL-1 beta -511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796). The genotype distributions of IL-1 beta + 3954 C/T (rs1143634) and IL-1 beta -511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796) were in Hardy-Weinberg equilibrium for the control group. Multivariate regression analyses showed that subjects carrying the rs1143634 TT genotype had a significantly increased risk of acute pancreatitis, with an adjusted odds ratio (95% confidence interval) of 2.11 (1.03-4.51). Subjects carrying the IL-1 beta rs1143634 TT genotype had a significantly increased risk of acute pancreatitis in our Chinese population.
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收藏
页码：975 / 980
页数：6
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