Do the EULAR Sjogren's syndrome outcome measures correlate with health status in primary Sjogren's syndrome?

被引：23

作者：

Lendrem, Dennis ^{[1
,2
]}

Mitchell, Sheryl ^{[1
]}

McMeekin, Peter ^{[3
]}

Gompels, Luke ^{[4
]}

Hackett, Katie ^{[1
,2
]}

Bowman, Simon ^{[5
]}

Price, Elizabeth ^{[6
]}

Pease, Colin T. ^{[7
,8
]}

Emery, Paul ^{[7
,8
]}

Andrews, Jacqueline ^{[7
,8
]}

Lanyon, Peter ^{[9
]}

Hunter, John ^{[10
]}

Gupta, Monica ^{[10
]}

Bombardieri, Michele ^{[11
,12
]}

Sutcliffe, Nurhan ^{[11
,12
]}

Pitzalis, Costantino ^{[11
,12
]}

McLaren, John ^{[13
]}

Cooper, Annie ^{[14
]}

Regan, Marian ^{[15
]}

Giles, Ian ^{[16
]}

Isenberg, David ^{[16
]}

Saravanan, Vadivelu ^{[17
]}

Coady, David ^{[18
]}

Dasgupta, Bhaskar ^{[19
]}

McHugh, Neil ^{[20
]}

Young-Min, Steven ^{[21
]}

Moots, Robert ^{[22
]}

Gendi, Nagui ^{[23
]}

Akil, Mohammed ^{[24
]}

Griffiths, Bridget ^{[1
]}

Ng, Wan-Fai ^{[1
,2
]}

Registry, Uk Primary Sjogren's Syndrome

机构：

[1] Newcastle Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England

[2] Newcastle Univ, Inst Cellular Med, Musculoskeletal Res Grp, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[3] Newcastle Univ, NIHR Biomed Res Ctr Ageing & Chron Dis, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[4] Taunton & Somerset NHS Fdn Trust, Musgrove Pk Hosp, Taunton, Somerset, England

[5] Univ Hosp Birmingham, Birmingham, W Midlands, England

[6] Great Western Hosp NHS Fdn Trust, Swindon, Wilts, England

[7] Univ Leeds, Leeds Inst Mol Med, Sect Musculoskeletal Dis, Leeds, W Yorkshire, England

[8] Leeds Teaching Hosp Trust, NIHR Leeds Musculoskeletal Biomed Res Unit, Leeds, W Yorkshire, England

[9] Univ Nottingham Hosp, Nottingham NG7 2UH, England

[10] Gartnavel Royal Hosp, Glasgow, Lanark, Scotland

[11] Barts & London NHS Trust, London, England

[12] Barts & London Queen Marys Sch Med & Dent, London, England

[13] Whytemans Brae Hosp, NHS Fife, Kirkcaldy, Scotland

[14] Royal Hampshire Cty Hosp, Winchester, Hants, England

[15] Royal Derby Hosp, Derby, England

[16] Univ Coll London Hosp NHS Fdn Trust, London, England

[17] Queen Elizabeth Hosp, Gateshead, England

[18] Sunderland Royal Hosp, Sunderland, England

[19] Southend Univ Hosp, Bath, Avon, England

[20] Royal Natl Hosp Rheumat Dis, Bath BA1 1RL, Avon, England

[21] Portsmouth Hosp NHS Trust, Portsmouth, Hants, England

[22] Aintree Univ Hosp NHS Fdn Trust, Liverpool L9 7AL, Merseyside, England

[23] Basildon Hosp, Basildon, England

[24] Royal Hallamshire Hosp, Sheffield S10 2JF, S Yorkshire, England

来源：

RHEUMATOLOGY | 2015年 / 54卷 / 04期

基金：

英国医学研究理事会;

关键词：

primary Sjogren's syndrome; outcome measures; utility values; quality of life; disease activity; patient-reported outcomes; DISABILITY; SF-6D; EQ-5D;

D O I：

10.1093/rheumatology/keu361

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. This study sets out to investigate the relationship between health status [EuroQol five-dimensions questionnaire (EQ-5D)] in primary SS and three of the European League Against Rheumatism (EULAR) SS outcome measures-the disease activity index (ESSDAI), the patient reported index (ESSPRI) and the sicca score. In particular, the goal was to establish whether there is a relationship between the EULAR outcome measures and quality of life. Methods. Health status was evaluated using a standardized measure developed by the EuroQol Group-the EQ5D. This permits calculation of two measures of health status: time trade-off (TTO) values and the EQ-5D visual analogue scale (VAS) scores. We used Spearman's rank correlation analysis to investigate the strength of association between health status and three EULAR measures of physician- and patient-reported disease activity in 639 patients from the UK primary SS registry (UKPSSR) cohort. Results. This study demonstrates that the EULAR SS disease-specific outcome measures are significantly correlated with health outcome values (P < 0.001). Higher scores on the ESSDAI, EULAR sicca score and ESSPRI are associated with poorer health states-i.e. lower TTO values and lower VAS scores. While all three are significantly correlated with TTO values and EQ-5D VAS scores, the effect is strongest for the ESSPRI. Conclusion. This study provides further evidence supporting the use of ESSDAI, EULAR sicca score and ESSPRI measures in the clinic. We also discuss the need for disease-specific measures of health status and their comparison with standardized health outcome measures.

引用

页码：655 / 659

页数：5

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