Folate-Decorated Succinylchitosan Nanoparticles Conjugated with Doxorubicin for Targeted Drug Delivery

被引：36

作者：

Sahu, Sumanta Kumar ^{[1
]}

Maiti, Swatilekha ^{[2
]}

Maiti, Tapas Kumar ^{[2
]}

Ghosh, Sudip K. ^{[2
]}

Pramanik, Panchanan ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kharagpur 721302, WB, India

[2] Indian Inst Technol, Dept Biotechnol, Kharagpur 721302, WB, India

来源：

MACROMOLECULAR BIOSCIENCE | 2011年 / 11卷 / 02期

关键词：

cancer therapy; chitosan; doxorubicin; drug delivery systems; nanoparticles; IN-VITRO; GENE DELIVERY; CHITOSAN; RECEPTOR; HYDROGELS; RELEASE; CELLS; CYCLODEXTRIN; ADSORPTION; LIPOSOMES;

D O I：

10.1002/mabi.201000353

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amphiphilic biodegradable succinylchitosan nanoparticles modified with folic acid are described that act as an emulsifier to form nanoparticles. Their molecular structures and physicochemical as well as self-assembly properties are characterized by means of FT-IR, H-1 NMR, FESEM, DLS, and TEM. The nanoparticles are 60-80 nm in size and are not toxic in vitro. They are immobilized with the cytostatic drug doxorubicin. Specific transport of doxorubicin by the nanoparticles into the folate-receptor-overexpressing cancer cells and its biological activity as well as in vitro release are demonstrated. It is shown that under acidic condition more drug is released. The nanoparticles can thus not only specifically deliver doxorubicin to its target, but also release the drug depending on the pH.

引用

页码：285 / 295

页数：11

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