Synthesis of spirooxindole pyrimidines catalyzed by silica-bonded N-propyltriethylenetetramine as a recyclable solid base catalyst in aqueous medium

被引：25
作者：
Niknam, Khodabakhsh [1 ]
Abolpour, Parisa [1 ]
机构：
[1] Persian Gulf Univ, Fac Sci, Dept Chem, Bushehr 75169, Iran
来源：
MONATSHEFTE FUR CHEMIE | 2015年 / 146卷 / 04期
关键词：
Heterogeneous catalyst; Solid base; Silica-bonded N-propyltriethylenetetramine; Barbituric acid; Spirooxindole pyrimidines; Water; ONE-POT SYNTHESIS; GARDNERIA-MULTIFLORA MAKINO; ASYMMETRIC TOTAL-SYNTHESIS; MAMMALIAN-CELL CYCLE; INDOLE ALKALOIDS; SULFAMIC ACID; ENANTIOSELECTIVE SYNTHESIS; CHEMOSELECTIVE SYNTHESIS; (-)-SPIROTRYPROSTATIN B; COMBINATORIAL SYNTHESIS;
D O I：
10.1007/s00706-014-1343-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Silica-bonded N-propyltriethylenetetramine was used as a heterogeneous solid base catalyst for the synthesis of spirooxindole pyrimidines by a one-pot condensation reaction of isatin, activated methylene reagent, and barbituric acid or thiobarbituric acid in aqueous medium in good to high yields. Catalyst could be recycled for several times without any additional treatment.
引用
收藏
页码：683 / 690
页数：8
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