The Impact of Hyaluronic Acid on Tendon Physiology and Its Clinical Application in Tendinopathies

被引：38

作者：

Oliva, Francesco ^{[1
,2
]}

Marsilio, Emanuela ^{[1
,2
]}

Asparago, Giovanni ^{[1
,2
]}

Frizziero, Antonio ^{[3
]}

Berardi, Anna Concetta ^{[4
]}

Maffulli, Nicola ^{[1
,5
,6
]}

机构：

[1] Univ Salerno, Fac Med & Surg, Dept Musculoskeletal Disorders, I-84084 Baronissi, Italy

[2] Osped San Giovanni Dio & Ruggi Aragona, Clin Ortoped, I-84131 Salerno, Italy

[3] Univ Parma, Dept Med & Surg, Phys & Rehabil Med Unit, I-43126 Parma, Italy

[4] Santo Spirito Hosp, Dept Haematol, Lab Stem Cells Transfus Med & Biotechnol, I-65123 Pescara, Italy

[5] Queen Mary Univ London, Mile End Hosp, Ctr Sports & Exercise Med, Barts & London Sch Med & Dent, 275 Bancroft Rd, London E1 4DG, England

[6] Keele Univ, Sch Pharm & Bioengn, Fac Med, Thornburrow Dr, Stoke On Trent ST4 7QB, Staffs, England

来源：

CELLS | 2021年 / 10卷 / 11期

关键词：

hyaluronic acid; receptor; biology; structure; tendon; tendinopathy; degeneration; inflammation; viscoelastic; hygroscopic; effect; SODIUM HYALURONATE; CELL-SURFACE; INTRACELLULAR HYALURONAN; ACHILLES TENDINOPATHY; LATERAL EPICONDYLITIS; CHONDROITIN SULFATE; ARTICULAR-CARTILAGE; GENE-EXPRESSION; IN-VITRO; INJECTIONS;

D O I：

10.3390/cells10113081

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The physical-chemical, structural, hydrodynamic, and biological properties of hyaluronic acid within tendons are still poorly investigated. Medical history and clinical applications of hyaluronic acid for tendinopathies are still debated. In general, the properties of hyaluronic acid depend on several factors including molecular weight. Several preclinical and clinical experiences show a good efficacy and safety profile of hyaluronic acid, despite the absence of consensus in the literature regarding the classification according to molecular weight. In in vitro and preclinical studies, hyaluronic acid has shown physical-chemical properties, such as biocompatibility, mucoadhesivity, hygroscopicity, and viscoelasticity, useful to contribute to tendon healing. Additionally, in clinical studies, hyaluronic acid has been used with promising results in different tendinopathies. In this narrative review, findings encourage the clinical application of HA in tendinopathies such as rotator cuff, epicondylitis, Achilles, and patellar tendinopathy.

引用

页数：13

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