Synthesis of fused indoles by sequential palladium-catalyzed Heck reaction and N-heteroannulation

被引：43

作者：

Söderberg, BCG ^{[1
]}

Hubbard, JW ^{[1
]}

Rector, SR ^{[1
]}

O'Neil, SN ^{[1
]}

机构：

[1] W Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA

来源：

TETRAHEDRON | 2005年 / 61卷 / 15期

基金：

美国国家卫生研究院;

关键词：

palladium-catalyzed; indoles; reductive; annulation;

D O I：

10.1016/j.tet.2005.02.033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A route to 3,4-fused indoles via two consecutive palladium-catalyzed reactions; an intramolecular Heck reaction followed by a reductive N-heteroannulation is described. Using this route, a number of indoles have been prepared having a variety of ring sizes anchored to the 3- and 4-position of the indole nucleus. Furthermore, a number of functional groups, both carbon and heteroatom substituents can be introduced in (and on) the additional ring without any detrimental effects on the two reactions. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3637 / 3649

页数：13

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