Latest Advances in Cryogel Technology for Biomedical Applications

被引：252

作者：

Memic, Adnan ^{[1
,2
,3
]}

Colombani, Thibault ^{[3
]}

Eggermont, Loek J. ^{[3
,4
]}

Rezaeeyazdi, Mahboobeh ^{[3
]}

Steingold, Joseph ^{[5
]}

Rogers, Zach J. ^{[3
]}

Navare, Kasturi Joshi ^{[3
]}

Mohammed, Halimatu S. ^{[3
]}

Bencherif, Sidi A. ^{[3
,6
,7
,8
]}

机构：

[1] King Abdulaziz Univ, Ctr Nanotechnol, Jeddah 21589, Saudi Arabia

[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Ctr Biomed Engn, Cambridge, MA 02139 USA

[3] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA

[4] Radboud Univ Nijmegen, Med Ctr, Radboud Inst Mol Life Sci, Dept Tumor Immunol,Oncode Inst, NL-6500 BC Nijmegen, Netherlands

[5] Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02115 USA

[6] Northeastern Univ, Dept Bioengn, Boston, MA 02115 USA

[7] Harvard Univ, Harvard John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA

[8] Univ Technol Compiegne, Sorbonne Univ, CNRS, UTC,UMR 7338,Biomech & Bioengn BMBI, F-60159 Compiegne, France

来源：

ADVANCED THERAPEUTICS | 2019年 / 2卷 / 04期

关键词：

biomaterials; bioseparation; cryogels; immunotherapy; tissue engineering; INDUCED PHASE-SEPARATION; MOLECULARLY IMPRINTED CRYOGEL; CHITOSAN-ALGINATE SCAFFOLDS; POLY(2-HYDROXYETHYL METHACRYLATE) HYDROGELS; MONOCLONAL-ANTIBODY PRODUCTION; POTENTIAL HEPATOCYTE CARRIERS; SUPERCRITICAL CARBON-DIOXIDE; POLY(VINYL ALCOHOL) CRYOGEL; MESENCHYMAL STROMAL CELLS; PLASMID DNA PURIFICATION;

D O I：

10.1002/adtp.201800114

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There exists a technological need for advanced materials with improved properties for emerging biomedical applications. Recent developments in macroporous materials have demonstrated their applicability as indispensable tools in biomedical research. Cryogels, which are materials with a macroporous 3D structure, are produced as a result of controlled freezing during polymerization with a highly interconnected polymer network. Cryogels' interest lies in their ability to address some of the limitations of their hydrogel analogues. In this review, hydrogel and cryogel basic concepts are discussed as a short primer for readers unfamiliar with the cryogels literature. Next, a general overview of the methods for synthesis and characterization of cryogels is provided, highlighting key concepts relevant to cryogels and explaining their unique properties. Finally an in-depth overview of specific technologies and fields where cryogels have been applied is given. It is argued that the latest advances in cryogel technologies are able to address challenges in bioseparation, tissue engineering, and other emerging bioengineering disciplines.

引用

页数：45

共 444 条

[1] O-carboxymethyl chitosan Schiff base complexes as affinity ligands for immobilized metal-ion affinity chromatography of lysozyme [J].