PARP inhibitors in the management of breast cancer: current data and future prospects

被引：206

作者：

Livraghi, Luca ^{[1
]}

Garber, Judy E. ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA

来源：

BMC MEDICINE | 2015年 / 13卷

关键词：

BRCA; Breast cancer; PARP inhibitors; Poly(ADP-ribose) polymerases; POLY(ADP-RIBOSE) POLYMERASE INHIBITOR; RECOMBINATION DEFICIENCY HRD; RECURRENT EPITHELIAL OVARIAN; REFRACTORY SOLID TUMORS; PHASE-1; DOSE-ESCALATION; EPOTHILONE-B ANALOG; II CLINICAL-TRIAL; DNA-REPAIR DEFECT; BRCA MUTANT-CELLS; HOMOLOGOUS RECOMBINATION;

D O I：

10.1186/s12916-015-0425-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Poly(ADP-ribose) polymerases (PARP) are enzymes involved in DNA-damage repair. Inhibition of PARPs is a promising strategy for targeting cancers with defective DNA-damage repair, including BRCA1 and BRCA2 mutation-associated breast and ovarian cancers. Several PARP inhibitors are currently in trials in the adjuvant, neoadjuvant, and metastatic settings for the treatment of ovarian, BRCA-mutated breast, and other cancers. We herein review the development of PARP inhibitors and the basis for the excitement surrounding these agents, their use as single agents and in combinations, as well as their toxicities, mechanisms of acquired resistance, and companion diagnostics.

引用

页数：16

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