Controlling and Switching the Morphology of Micellar Nanoparticles with Enzymes

被引：138

作者：

Ku, Ti-Hsuan ^{[1
]}

Chien, Miao-Ping ^{[1
]}

Thompson, Matthew P. ^{[1
]}

Sinkovits, Robert S. ^{[1
,2
]}

Olson, Norman H. ^{[1
]}

Baker, Timothy S. ^{[1
,3
]}

Gianneschi, Nathan C. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, San Diego Supercomp Ctr, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 22期

基金：

美国国家科学基金会;

关键词：

BLOCK-COPOLYMER MICELLES; PEPTIDE-AMPHIPHILE NANOFIBERS; CROSS-LINKED NANOPARTICLES; SMALL-ANGLE SCATTERING; DIBLOCK COPOLYMERS; POLYMERIC MICELLES; MATRIX METALLOPROTEINASES; BIOMEDICAL APPLICATIONS; PROTEIN-KINASE; DRUG-DELIVERY;

D O I：

10.1021/ja2004736

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Micelles were prepared from polymer-peptide block copolymer amphiphiles containing substrates for protein kinase A, protein phosphatase-1, and matrix metalloproteinases 2 and 9. We examine reversible switching of the morphology of these micelles through a phosphorylation dephosphorylation cycle and study peptide-sequence directed changes in morphology in response to proteolysis. Furthermore, the exceptional uniformity of these polymer-peptide particles makes them amenable to cryo-TEM reconstruction techniques lending insight into their internal structure.

引用

页码：8392 / 8395

页数：4

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