Iodine-Mediated Domino Cyclization for One-Pot Synthesis of Indolizine-Fused Chromones via Metal-Free sp3 C-H Functionalization

被引：16

作者：

Zhang, Xiang-Jin ^{[1
]}

Wang, Zhuo ^{[1
]}

Zhang, Han ^{[1
]}

Gao, Jing-Jing ^{[1
]}

Yang, Kai-Rui ^{[1
]}

Fan, Wei-Yu ^{[1
]}

Wu, Rui-Xue ^{[1
]}

Feng, Meng-Lin ^{[1
]}

Zhu, Wei ^{[1
]}

Zhu, Yan-Ping ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ,Collaborat Innovat Ctr Adv Drug Deliv, Yantai 264005, Shandong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 01期

基金：

中国国家自然科学基金;

关键词：

D TRIMETHYL ETHER; CATALYZED SYNTHESIS; FACILE SYNTHESIS; LAMELLARIN D; ANNULATION; DERIVATIVES; PYRIDINE; CLEAVAGE; CASCADE; YLIDES;

D O I：

10.1021/acs.joc.1c02508

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of new indolizine-fused chromones has been accomplished from ethyl (E)-3-(2-acetylphenoxy)acrylates and pyridines in a "one-pot" manner. Facile operation in open-air, metal-free, and mild conditions renders this protocol particularly practical and attractive. Moreover, this method can simultaneously construct two molecular fragments of chromone and indolizine. Scale-up experiment and the construction of natural products further prove the practicability of this strategy.

引用

页码：835 / 845

页数：11

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