Prognostic impact of infection in octogenarians with ST-segment elevation myocardial infarction

Key summary pointsAim The aim of this study was to investigate the impact and prognostic value of infection on long-term mortality in octogenarian patients with STEMI. Findings Patients with infection had a higher rate of in-hospital and long-term mortality. Message Infection is an independent predictor of long-term mortality in octogenarian patients with STEMI. Purpose Contemporary studies assessing outcomes in octogenarian patients presenting with ST-segment elevation myocardial infarction (STEMI) and infection are scarce. This study investigated the impact and prognostic value of infection on long-term mortality in octogenarian patients with STEMI. Methods A total of 1564 patients admitted with STEMI between May 2015 and September 2019 were retrospectively analyzed, and 110 octogenarians were identified and included. Predictors of mortality were determined by multivariate Cox regression analysis. Survival curves were generated using the Kaplan-Meier method. Results The mean age of the patients was 85 +/- 4 years, and 58 (52%) were male. Median follow-up was 41 months. Patients with infection had higher rates of in-hospital (16.4% vs. 8.2%,p = 0.001) and long-term (33.6% vs. 20%,p = 0.001) mortality. Multivariate Cox regression analysis revealed that infection (HR 3.16; 95% CI 1.52-6.59;p = 0.002) and C-reactive protein levels (HR 0.99; 95% CI 0.98-1.00;p = 0.042) were independent predictors of mortality in patients with infection. Kaplan-Meier analysis also showed that patients with infection had a significantly higher mortality rate (p < 0.001). Conclusion Infection is an independent predictor of long-term mortality in octogenarian patients with STEMI.