Mitochondria in skeletal muscle: Adaptable rheostats of apoptotic susceptibility

被引：30

作者：

Adhihetty, Peter J. ^{[2
]}

O'Leary, Mchael F. N. ^{[1
]}

Hood, David A. ^{[1
,3
]}

机构：

[1] York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON M3J 1P3, Canada

[2] Cornell Univ, Dept Neurol & Neurosci, New York, NY 10021 USA

[3] York Univ, Dept Biol, Toronto, ON M3J 1P3, Canada

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2008年 / 36卷 / 03期

关键词：

atrophy; sarcopenia; exercise; reactive oxygen species; mitochondrial myopathy; apoptosis; mitochondrial permeability transition pore;

D O I：

10.1097/JES.0b013e31817be7b7

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Apoptosis is an essential process that plays a critical role in both tissue development and maintenance. Apoptosis has been shown to be involved in skeletal muscle atrophy resulting from chronic muscular disuse, sarcopenia, and mitochondrial myopathies. Exercise may attenuate some of the proapoptotic adaptations that occur during these conditions. This review will focus on the factors influencing mitochondrially mediated apoptosis in skeletal muscle.

引用

页码：116 / 121

页数：6

共 31 条

[1] The effect of training on the expression of mitochondrial biogenesis- and apoptosis-related proteins in skeletal muscle of patients with mtDNA defects [J].

Adhihetty, Peter J. ;

Taivassalo, Tanja ;

Haller, Ronald G. ;

Walkinshaw, Donald R. ;

Hood, David A. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (03) :E672-E680

[2] Effect of denervation on mitochondrially mediated apoptosis in skeletal muscle [J].

Adhihetty, Peter J. ;

O'Leary, Michael F. N. ;

Chabi, Beatrice ;

Wicks, Karen L. ;

Hood, David A. .

JOURNAL OF APPLIED PHYSIOLOGY, 2007, 102 (03) :1143-1151

[3] Effect of chronic contractile activity on SS and IMF mitochondrial apoptotic susceptibility in skeletal muscle [J].

Adhihetty, Peter J. ;

Ljubicic, Vladimir ;

Hood, David A. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 292 (03) :E748-E755

[4] Differential susceptibility of subsarcolemmal and intermyofibrillar mitochondria to apoptotic stimuli [J].

Adhihetty, PJ ;

Ljubicic, V ;

Menzies, KJ ;

Hood, DA .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2005, 289 (04) :C994-C1001

[5]

Adhihetty PJ., 2003, BAM PADOVA, V13, P171

[6]

Allen DL, 1999, MUSCLE NERVE, V22, P1350, DOI 10.1002/(SICI)1097-4598(199910)22:10<1350::AID-MUS3>3.0.CO

[7]

2-8

[8]

Alway SE, 2003, J GERONTOL A-BIOL, V58, P687

[9] Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death [J].

Baines, Christopher P. ;

Kaiser, Robert A. ;

Sheiko, Tatiana ;

Craigen, William J. ;

Molkentin, Jeffery D. .

NATURE CELL BIOLOGY, 2007, 9 (05) :550-U122

[10] Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome [J].

Beere, HM ;

Wolf, BB ;

Cain, K ;

Mosser, DD ;

Mahboubi, A ;

Kuwana, T ;

Tailor, P ;

Morimoto, RI ;

Cohen, GM ;

Green, DR .

NATURE CELL BIOLOGY, 2000, 2 (08) :469-475

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