Stylissamide X, a new proline-rich cyclic octapeptide as an inhibitor of cell migration, from an Indonesian marine sponge of Stylissa sp.

被引：30

作者：

Arai, Masayoshi ^{[1
]}

Yamano, Yoshi ^{[1
]}

Fujita, Mayumi ^{[1
]}

Setiawan, Andi ^{[2
]}

Kobayashi, Motomasa ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[2] Lampung Univ, Fac Sci, Dept Chem, Bandar Lampung 35145, Indonesia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 04期

关键词：

Stylissamide X; Marine sponge; Cancer; Migration; Metastasis; ANTINEOPLASTIC AGENTS; STYLOTELLA-AURANTIUM; HYMENIACIDON-SP; HEPTAPEPTIDES; CARIBICA; CARTERI;

D O I：

10.1016/j.bmcl.2011.10.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new proline-rich cyclic octapeptide named stylissamide X (1) was isolated from an Indonesian marine sponge of Stylissa sp. as an inhibitor of cell migration from the guidance of wound-healing assay. The chemical structure of stylissamide X (1) was determined on the basis of spectroscopic analysis, and stereostructure of the amino acids were deduced by Marfey's method. Compound 1 showed inhibitory activity against migration of HeLa cells in the ranges of 0.1-10 mu M concentration through both wound-healing assay and chemotaxicell chamber assay, while the cell viability was maintained more than 75% up to 10 mu M concentration of 1. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1818 / 1821

页数：4

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