Plasma-Treated Nitrogen-Containing Surfaces for Cell Adhesion: The Role of the Polymeric Substrate

被引:20
作者
Lopez, Linda Caterina [1 ]
Belviso, Maria Rosaria [1 ]
Gristina, Roberto [2 ]
Nardulli, Marina [1 ]
d'Agostino, Riccardo [1 ,2 ,3 ]
Favia, Pietro [1 ,2 ,3 ]
机构
[1] Univ Bari, Dept Chem, I-70126 Bari, Italy
[2] Univ Bari, Inst Inorgan Methodol & Plasmas IMIP CNR, I-70126 Bari, Italy
[3] Univ Bari, Plasma Solut Srl, I-70126 Bari, Italy
关键词
adhesion; ammonia discharges; cell adhesion; cell culture; HepG2; plasma treatment; surfaces;
D O I
10.1002/ppap.200731008
中图分类号
O59 [应用物理学];
学科分类号
摘要
Plasma processes have revealed to be, in the last decades, among the more powerful tools utilized for surface modification of polymers intended to be used in the biomedical field. In particular, two main plasma processes have been widely used: the deposition of thin films and the grafting of functional groups (plasma treatments). For this work two different polymers, polyethylene terephthalate and polystyrene were grafted with nitrogen-containing groups to enhance cell response. NH(2) functionalities were used as anchor groups for the immobilization of galactosamine. Hepatocytes cells, HepG2, were seeded onto modified samples to assess cell biocompatibility of N- and Gal-containing substrates. For both polymers, cell culture results clearly show that cells grown on N-grafted and Gal-immobilized substrates displayed a different cell behaviour.
引用
收藏
页码:S402 / S405
页数:4
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