Large Cell Neuroendocrine Carcinoma Harboring an Anaplastic Lymphoma Kinase (ALK) Rearrangement with Response to Alectinib

被引：37

作者：

Hayashi, Nobuyoshi ^{[1
,2
]}

Fujita, Akihisa ^{[1
]}

Saikai, Toyohiro ^{[1
]}

Takabatake, Hirotugu ^{[1
]}

Sotoshiro, Mie ^{[1
]}

Sekine, Kyuutarou ^{[1
]}

Kawana, Akihiko ^{[2
]}

机构：

[1] Sapporo Minamisanjyou Hosp, Dept Resp Med, Sapporo, Hokkaido, Japan

[2] Natl Def Med Coll, Dept Internal Med, Div Infect Dis & Pulm Med, Tokorozawa, Saitama, Japan

来源：

INTERNAL MEDICINE | 2018年 / 57卷 / 05期

关键词：

LCNEC; pulmonary neuroendocrine carcinoma; ALK rearrangement and alectinib; POSITIVE LUNG-CANCER; EML4-ALK FUSION; CRIZOTINIB; ADENOCARCINOMA; CHEMOTHERAPY; INHIBITOR; COMPONENT;

D O I：

10.2169/internalmedicine.9368-17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anaplastic lymphoma kinase (ALK) rearrangement is most commonly observed in lung adenocarcinoma in a subset of lung cancer. Large cell neuroendocrine carcinoma (LCNEC) harboring an ALK rearrangement is very rare. Based on the findings from a transbronchial lung biopsy, a 75-year-old non-smoking woman was diagnosed with LCNEC with multiple liver and bone metastases. After seven cycles of cytotoxic chemotherapy, her genotype testing demonstrated ALK rearrangement. Subsequently, she was administered alectinib and exhibited a partial response.

引用

页码：713 / 716

页数：4

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