Hematopoietic-Stem-Cell-Based Gene Therapy for HIV Disease

被引：100

作者：

Kiem, Hans-Peter ^{[2
,4
,5
]}

Jerome, Keith R. ^{[3
,6
]}

Deeks, Steven G. ^{[7
]}

McCune, Joseph M. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA 94110 USA

[2] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA

[3] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA

[4] Univ Washington, Dept Med, Seattle, WA 98109 USA

[5] Univ Washington, Dept Pathol, Seattle, WA 98109 USA

[6] Univ Washington, Dept Lab Med, Seattle, WA 98109 USA

[7] Univ Calif San Francisco, HIV AIDS Program, San Francisco, CA 94110 USA

来源：

CELL STEM CELL | 2012年 / 10卷 / 02期

关键词：

BLOOD PROGENITOR CELLS; MARROW REPOPULATING CELLS; IN-VIVO; T-CELLS; MULTILINEAGE HEMATOPOIESIS; EFFICIENT TRANSDUCTION; LENTIVIRAL VECTOR; MURINE MARROW; SELF-RENEWAL; IMMUNODEFICIENCY;

D O I：

10.1016/j.stem.2011.12.015

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Although combination antiretroviral therapy can dramatically reduce the circulating viral load in those infected with HIV, replication-competent virus persists. To eliminate the need for indefinite treatment, there is growing interest in creating a functional HIV-resistant immune system through the use of gene-modified hematopoietic stem cells (HSCs). Proof of concept for this approach has been provided in the instance of an HIV-infected adult transplanted with allogeneic stem cells from a donor lacking the HIV coreceptor, CCR5. Here, we review this and other strategies for HSC-based gene therapy for HIV disease. © 2012 Elsevier Inc.

引用

页码：137 / 147

页数：11

共 50 条

[41] Stem Cell Gene Therapy for HIV: Strategies to Inhibit Viral Entry and Replication
David L. DiGiusto
Current HIV/AIDS Reports, 2015, 12 : 79 - 87
[42] Hematopoietic Stem Cell Niche in Health and Disease
Hoggatt, Jonathan
Kfoury, Youmna
Scadden, David T.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11, 2016, 11 : 555 - 581
[43] Combinatorial RNA-based gene therapy for the treatment of HIV/AIDS
Chung, Janet
DiGiusto, David L.
Rossi, John J.
EXPERT OPINION ON BIOLOGICAL THERAPY, 2013, 13 (03) : 437 - 445
[44] The hematopoietic stem cell niche in homeostasis and disease
Calvi, Laura M.
Link, Daniel C.
BLOOD, 2015, 126 (22) : 2443 - 2451
[45] An efficient method for single hematopoietic stem cell engraftment in mice based on cell-cycle dormancy of hematopoietic stem cells
Abe, Takanori
Masuya, Masahiro
Ogawa, Makio
EXPERIMENTAL HEMATOLOGY, 2010, 38 (07) : 603 - 608
[46] Epigenetics of hematopoietic stem cell aging and disease
Oshima, Motohiko
Iwama, Atsushi
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2014, 100 (04) : 326 - 334
[47] Screening chimeric GAA variants in preclinical study results in hematopoietic stem cell gene therapy candidate vectors for Pompe disease
Dogan, Yildirim
Barese, Cecilia N.
Schindler, Jeffrey W.
Yoon, John K.
Unnisa, Zeenath
Guda, Swaroopa
Jacobs, Mary E.
Oborski, Christine
Maiwald, Tim
Clarke, Diana L.
Schambach, Axel
Pfeifer, Richard
Harper, Claudia
Mason, Chris
van Til, Niek P.
MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT, 2022, 27 : 464 - 487
[48] Hematopoietic Stem Cell Heterogeneity
Jurecic, Roland
STEM CELLS HETEROGENEITY IN DIFFERENT ORGANS, 2019, 1169 : 195 - 211
[49] Hematopoietic Stem Cell and Gene Therapy Corrects Primary Neuropathology and Behavior in Mucopolysaccharidosis IIIA Mice
Langford-Smith, Alexander
Wilkinson, Fiona L.
Langford-Smith, Kia J.
Holley, Rebecca J.
Sergijenko, Ana
Howe, Steven J.
Bennett, William R.
Jones, Simon A.
Wraith, J. E.
Merry, Catherine L. R.
Wynn, Robert F.
Bigger, Brian W.
MOLECULAR THERAPY, 2012, 20 (08) : 1610 - 1621
[50] Update on Clinical Ex Vivo Hematopoietic Stem Cell Gene Therapy for Inherited Monogenic Diseases
Tucci, Francesca
Scaramuzza, Samantha
Aiuti, Alessandro
Mortellaro, Alessandra
MOLECULAR THERAPY, 2021, 29 (02) : 489 - 504

← 1 2 3 4 5 →