Hematopoietic-Stem-Cell-Based Gene Therapy for HIV Disease

被引：100

作者：

Kiem, Hans-Peter ^{[2
,4
,5
]}

Jerome, Keith R. ^{[3
,6
]}

Deeks, Steven G. ^{[7
]}

McCune, Joseph M. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA 94110 USA

[2] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA

[3] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA

[4] Univ Washington, Dept Med, Seattle, WA 98109 USA

[5] Univ Washington, Dept Pathol, Seattle, WA 98109 USA

[6] Univ Washington, Dept Lab Med, Seattle, WA 98109 USA

[7] Univ Calif San Francisco, HIV AIDS Program, San Francisco, CA 94110 USA

来源：

CELL STEM CELL | 2012年 / 10卷 / 02期

关键词：

BLOOD PROGENITOR CELLS; MARROW REPOPULATING CELLS; IN-VIVO; T-CELLS; MULTILINEAGE HEMATOPOIESIS; EFFICIENT TRANSDUCTION; LENTIVIRAL VECTOR; MURINE MARROW; SELF-RENEWAL; IMMUNODEFICIENCY;

D O I：

10.1016/j.stem.2011.12.015

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Although combination antiretroviral therapy can dramatically reduce the circulating viral load in those infected with HIV, replication-competent virus persists. To eliminate the need for indefinite treatment, there is growing interest in creating a functional HIV-resistant immune system through the use of gene-modified hematopoietic stem cells (HSCs). Proof of concept for this approach has been provided in the instance of an HIV-infected adult transplanted with allogeneic stem cells from a donor lacking the HIV coreceptor, CCR5. Here, we review this and other strategies for HSC-based gene therapy for HIV disease. © 2012 Elsevier Inc.

引用

页码：137 / 147

页数：11

共 50 条

[21] Historical Perspective on the Current Renaissance for Hematopoietic Stem Cell Gene Therapy
Kohn, Donald B.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2017, 31 (05) : 721 - +
[22] Mouse models in hematopoietic stem cell gene therapy and genome editing
Radtke, Stefan
Humbert, Olivier
Kiem, Hans-Peter
BIOCHEMICAL PHARMACOLOGY, 2020, 174
[23] Dyskeratosis congenita future: Hematopoietic stem cell transplantation or gene therapy?
Manoochehrabadi, Saba
Behfar, Maryam
Ahmadvand, Mohammad
Hamidieh, Amir Ali
GENE REPORTS, 2025, 38
[24] Hematopoietic stem cell gene therapy: The optimal use of lentivirus and gene editing approaches
Lamsfus-Calle, Andres
Daniel-Moreno, Alberto
Urena-Bailen, Guillermo
Raju, Janani
Antony, Justin S.
Handgretinger, Rupert
Mezger, Markus
BLOOD REVIEWS, 2020, 40
[25] Stem Cell Based Cancer Gene Therapy
Cihova, Marina
Altanerova, Veronika
Altaner, Cestmir
MOLECULAR PHARMACEUTICS, 2011, 8 (05) : 1480 - 1487
[26] Enrichment of Human Hematopoietic Stem/Progenitor Cells Facilitates Transduction for Stem Cell Gene Therapy
Baldwin, Kismet
Urbinati, Fabrizia
Romero, Zulema
Campo-Fernandez, Beatriz
Kaufman, Michael L.
Cooper, Aaron R.
Masiuk, Katelyn
Hollis, Roger P.
Kohn, Donald B.
STEM CELLS, 2015, 33 (05) : 1532 - 1542
[27] CCR5-Targeted Hematopoietic Stem Cell Gene Approaches for HIV Disease: Current Progress and Future Prospects
Lai, Yu
CURRENT STEM CELL RESEARCH & THERAPY, 2012, 7 (04) : 310 - 317
[28] Development of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome
Boztug, Kaan
Dewey, Ricardo A.
Klein, Christoph
CURRENT OPINION IN MOLECULAR THERAPEUTICS, 2006, 8 (05) : 390 - 395
[29] Development of Hematopoietic Stem Cell Based Gene Therapy for HIV-1 Infection: Considerations for Proof of Concept Studies and Translation to Standard Medical Practice
DiGiusto, David L.
Stan, Rodica
Krishnan, Amrita
Li, Haitang
Rossi, John J.
Zaia, John A.
VIRUSES-BASEL, 2013, 5 (11): : 2898 - 2919
[30] Advancements in Hematopoietic Stem Cell Gene Therapy: A Journey of Progress for Viral Transduction
Giommetti, Aurora
Papanikolaou, Eleni
CELLS, 2024, 13 (12)

← 1 2 3 4 5 →