The Relationship Between Serum Uric Acid Levels and Clinical Features in Essential Tremor

被引:4
作者
Gozubatik Celik, R. Gokcen [1 ]
Koksal, Ayhan [1 ]
Sahin, Buket [1 ]
Sen, Aysu [1 ]
Karagoz Sakalli, Nazan [1 ]
Nalbantoglu, Mecbure [2 ]
机构
[1] Bakirkoy Res & Training Hosp Neurol & Psychiat Di, Dept Neurol, Istanbul, Turkey
[2] Bilim Univ, Dept Neurol, Sch Med, Istanbul, Turkey
来源
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY | 2020年 / 57卷 / 01期
关键词
Essential tremor; uric acid; Fahn-Tolosa-Marin tremor scale; familial essential tremor; sporadic essential tremor; antioxidant effect; PARKINSONS-DISEASE; ASSOCIATION; PATHOPHYSIOLOGY; PROGRESSION;
D O I
10.29399/npa.24761
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: In this study, we aimed to investigate the effect of uric acid on the disease, its severity and progression in ET patients with partially co-clinical features with Parkinson's disease (PD). Methods: Serum UA levels of 87 consecutive ET patients were measured and were matched according to age and sex with 87 healthy controls. Fahn-Tolosa-Marin scale was used for the severity of tremor. Sociodemographic characteristics, type of ET, duration of disease, and treatment modalities were evaluated. Results: The mean uric acid level was calculated as 4.986 +/- 2.1458 mg/c11.. and 6.004 +/- 1.523 mg/dL in the patient and control groups, respectively (p <= 0.005). The blood UA level of patients with sporadic (n: 61) ET was found to be lower than the familial ET (n: 26) (p <= 0.005). The tremor severity of the family ET patients was lower than the sporadic ET (n: 61) (p <= 0.005). The mean blood UA level (4.429 +/- 1.216 mg/dL) in the patients with high total tremor severity scores (n: 48) was found lower than in the patients with low total tremor severity scores (n: 39) (5.673 +/- 2.106 mg/dL) (P=0.000). The serum UA level was significantly lower in the patients whose disease duration longer than 5 years than in patients whose duration of the disease was shorter than 5 years. 5.732 +/- 1.240 for >= 5 years; 6.438 +/- 0.286 <= 5 years) (P=0.001). Conclusion: We hypothesize that as a result of high antioxidant properties of high serum uric acid levels, it is a biomarker that can show disease risk and progression in patients with ET as well as PD.
引用
收藏
页码:33 / 36
页数:4
相关论文
共 29 条
[1]   Serum uric acid levels in patients with Parkinson's disease: Their relationship to treatment and disease duration [J].
Andreadou, Elisabeth ;
Nikolaou, Chryssoula ;
Gournaras, Filippos ;
Rentzos, Michael ;
Boufidou, Fotini ;
Tsoutsou, Anthoussa ;
Zournas, Christos ;
Zissimopoulos, Vassilis ;
Vassilopoulos, Demetrios .
CLINICAL NEUROLOGY AND NEUROSURGERY, 2009, 111 (09) :724-728
[2]   Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based study [J].
Benito-Leon, J. ;
Louis, E. D. ;
Bermejo-Pareja, F. .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2009, 80 (04) :423-425
[3]   Understanding the pathophysiology of essential tremor through advanced neuroimaging: A review [J].
Bhalsing, Ketaki S. ;
Saini, Jitender ;
Pal, Pramod Kr. .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2013, 335 (1-2) :9-13
[4]   Consensus Statement on the Classification of Tremors. From the Task Force on Tremor of the International Parkinson and Movement Disorder Society [J].
Bhatia, Kailash P. ;
Bain, Peter ;
Bajaj, Nin ;
Elble, Rodger J. ;
Hallett, Mark ;
Louis, Elan D. ;
Raethjen, Jan ;
Stamelou, Maria ;
Testa, Claudia M. ;
Deuschl, Guenther .
MOVEMENT DISORDERS, 2018, 33 (01) :75-87
[5]   Uric acid activates extracellular signal-regulated kinases and thereafter endothelin-1 expression in rat cardiac fibroblasts [J].
Cheng, Tzu-Hurng ;
Lin, Jia-Wei ;
Chao, Hung-Hsin ;
Chen, Yen-Ling ;
Chen, Cheng-Hsien ;
Chan, Paul ;
Liu, Ju-Chi .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2010, 139 (01) :42-49
[6]   Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis [J].
Cipriani, S. ;
Chen, Xiqun ;
Schwarzschild, Michael A. .
BIOMARKERS IN MEDICINE, 2010, 4 (05) :701-712
[7]   Challenges in essential tremor genetics [J].
Clark, L. N. ;
Louis, E. D. .
REVUE NEUROLOGIQUE, 2015, 171 (6-7) :466-474
[8]   Essential tremor and cerebellar dysfunction -: Clinical and kinematic analysis of intention tremor [J].
Deuschl, G ;
Wenzelburger, R ;
Löffler, K ;
Raethjen, J ;
Stolze, H .
BRAIN, 2000, 123 :1568-1580
[9]   The essential tremor syndromes [J].
Elble, Rodger J. .
CURRENT OPINION IN NEUROLOGY, 2016, 29 (04) :507-512
[10]   Essential Pitfalls in "Essential" Tremor [J].
Espay, Alberto J. ;
Lang, Anthony E. ;
Erro, Roberto ;
Merola, Aristide ;
Fasano, Alfonso ;
Berardelli, Alfredo ;
Bhatia, Kailash P. .
MOVEMENT DISORDERS, 2017, 32 (03) :325-331