Lack of Association between ORAI1/CRACM1 Gene Polymorphisms and Kawasaki Disease in the Taiwanese Children

被引：19

作者：

Kuo, Ho-Chang ^{[2
,4
]}

Lin, Ying-Jui ^{[3
]}

Juo, Suh-Hang Hank ^{[1
,5
]}

Hsu, Yu-Wen ^{[1
]}

Chen, Wei-Chiao ^{[1
]}

Yang, Kuender D. ^{[2
,4
]}

Liang, Chi-Di ^{[3
]}

Yang, Shengyu ^{[6
,7
]}

Chao, Mei-Chyn ^{[1
,9
]}

Yu, Hong-Ren ^{[2
,4
]}

Wang, Shouyan ^{[8
]}

Lin, Li-Yan ^{[2
]}

Chang, Wei-Chiao ^{[1
,5
]}

机构：

[1] Kaohsiung Med Univ, Coll Med, Dept Med Genet, Kaohsiung 807, Taiwan

[2] Chang Gung Mem Hosp, Kaohsiung Med Ctr, Dept Pediat, Div Allergy Immunol & Rheumatol, Kaohsiung, Taiwan

[3] Chang Gung Mem Hosp, Kaohsiung Med Ctr, Div Cardiol, Dept Pediat, Kaohsiung, Taiwan

[4] Chang Gung Univ, Coll Med, Grad Inst Clin Med Sci, Kaohsiung, Taiwan

[5] Kaohsiung Med Univ, Ctr Excellence Environm Med, Kaohsiung 807, Taiwan

[6] Univ S Florida, H Lee Moffitt Canc Ctr, Comprehens Melanoma Res Ctr, Tampa, FL 33682 USA

[7] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Tumor Biol, Tampa, FL 33682 USA

[8] Univ Southampton, Inst Sound & Vibrat Res, Southampton, Hants, England

[9] Kaohsiung Med Univ Hosp, Div Genet Endocrinol & Metab, Dept Pediat, Kaohsiung 807, Taiwan

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2011年 / 31卷 / 04期

关键词：

Kawasaki disease; ORAI1/CRACM1; coronary artery lesions; intravenous immunoglobulin; IMMUNOGLOBULIN TREATMENT FAILURE; CORONARY-ARTERY LESIONS; HUMAN CORONAVIRUS; CHANNEL FUNCTION; CRAC CHANNEL; SUSCEPTIBILITY; INFECTION; JAPAN; ORAI1;

D O I：

10.1007/s10875-011-9524-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Kawasaki disease (KD) is characterized by systemic vasculitis of an unknown cause. A previous study has indicated that a polymorphism of the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene is involved in the susceptibility to KD. ORAI (also known as CRACM1) is one of the components of store-operated calcium channels involved in regulating immune and inflammatory reactions. This study was conducted to investigate if polymorphisms in ORAI1/CRACM1, a gene downstream from ITPKC, are associated with KD susceptibility and clinical outcomes. A total of 1,056 subjects (341 KD patients and 715 controls) were investigated to identify five tagging single nucleotide polymorphisms (tSNPs) in ORAI1/CRACM1 (rs12313273, rs6486795, rs7135617, rs12320939, and rs712853) by using the TaqMan Allelic Discrimination assay. No significant associations between genotype and allele frequency of the five ORAI1/CRACM1 tSNPs were observed in the KD patients and controls. In KD patients, no significant associations between ORAI1/CRACM1 polymorphisms and coronary artery lesion (CAL) formation or intravenous immunoglobulin (IVIG) treatment response were observed. The results from haplotype analysis were insignificant. This study showed for the first time that ORAI1/CRACM1 polymorphisms are not associated with KD susceptibility, CAL formation, or IVIG treatment response in the Taiwanese population.

引用

页码：650 / 655

页数：6

共 29 条

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