Palladium-mediated intramolecular C-N bond formation involving allyl substituted pyridines. Application to a novel strategy for the synthesis of the skeleton of berberinium derivatives

被引：27

作者：

Chengebroyen, J ^{[1
]}

Linke, M ^{[1
]}

Robitzer, M ^{[1
]}

Sirlin, C ^{[1
]}

Pfeffer, M ^{[1
]}

机构：

[1] Univ Strasbourg 1, Lab Synthese Metalloind, UMR 7513, F-67000 Strasbourg, France

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2003年 / 687卷 / 02期

关键词：

palladium-mediated synthesis; C-N bond formation; allenes; cyclopalladated complexes; fleterocyles; berberiniums;

D O I：

10.1016/j.jorganchem.2003.06.001

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The insertion of allenes in the Pd-C sigma bond of cyclopalladated pyridine derivatives afforded (eta(3)-allyl) Pd complexes. The ideally located imine unit reacted selectively with the allyl functionality to yield a series of new cationic heterocycles. The process opened the route to a novel strategy for the synthesis of berberiniums, a class of molecules of pharmacological interest. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：313 / 321

页数：9

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